CT引导3D打印模板辅助^(125)I粒子植入治疗恶性肿瘤的剂量学分析和疗效观察  

Dosimetric analysis and efficacy observation of CT-guided 3D-printing template assisted ^(125)I seed implantation in treating malignant tumors

作　　者：李洪均[1] 刘娜[1] 张建萍[1] 沈慧 陈兵 于鸿煦 刘雪辉[1] LI Hongjun;LIU Na;ZHANG Jianping;SHEn Hui;CHEN Bing;YU Hongxu;LIU Xuehui(Department of Nuclear Medicine,Tianjin Third Central Hospital,Tianjin 300170,China)

机构地区：[1]天津市第三中心医院核医学科,300170

出　　处：《重庆医学》2022年第19期3335-3338,共4页Chongqing medicine

摘　　要：目的观察分析CT引导3D打印模板辅助^(125)I粒子植入治疗恶性肿瘤的剂量学指标及近期疗效。方法回顾性分析2019年6月至2021年3月该院恶性肿瘤^(125)I粒子植入患者18例(男15例,女3例,中位年龄62岁)共21个病灶,比较术前治疗计划与术后验证计划中主要剂量学指标、术前计划与术后实际植入粒子数量的差异;术后3个月复查CT观察肿瘤病灶最长径变化,并进行疗效评估。结果术前和术后剂量学指标比较,差异均无统计学意义(P>0.05);实际植入粒子数量多于术前计划,差异有统计学意义[(63.52±27.80)颗vs.(60.24±25.98)颗,P=0.001];术后肿瘤病灶最长径小于术前,差异有统计学意义[(2.92±2.27)cm vs.(5.57±2.03)cm,P<0.001];术后3个月总有效率为81.0%,局部控制率为100.0%。结论模板辅助粒子治疗恶性肿瘤剂量精准,有效率高。Objective To observe and analyze the dosimetric indicators and short-term efficacy of CT-guided 3D-printing template assisted ^(125)I seed implantation in the treatment of malignant tumors.Methods A retrospective analysis was performed on 21 lesions in years old 18 patients(15 males,3 females,and a median age of 62)with ^(125)I seed implantation due to malignant tumors in this hospital from June 2019 to March 2021.The differences of main dosimetric indicators were compared between preoperative treatment plan and postoperative verification plan,and the preoperative planned and actual number of implanted seeds were compared,as well.The changes of the longest diameter of the tumor lesion were observed by rechecking CT in postoperative 3 months and the efficacy was evaluated.Results There was no statistically significant difference between the pre-and post-operative dosimetric indicators(P>0.05).The number of actually implanted seeds was more than that of the preoperative planned seeds,and the difference was statistically significant[(63.52±27.80)seeds vs.(60.24±25.98)seeds,P=0.001].The longest diameter of tumor lesions after operation was smaller than that before operation,and the difference was statistically significant[(2.92±2.27)cm vs.(5.57±2.03)cm,P<0.001].The overall effective rate for postoperative 3 months was 81.0%,and the local control rate was 100.0%.Conclusion The dose in the template assisted seed implantation for treating malignant tumors is accurate with high effective rate.

关 键 词：CT引导 3D打印模板 放射性粒子 植入 恶性肿瘤 疗效 

分 类 号：R730.55[医药卫生—肿瘤]