囊性脑膜瘤临床特点及显微手术后继发癫痫的危险因素  

Analysis of clinical characteristics of cystic meningioma and risk factors for epilepsy after microsurgery

作　　者：齐晏 李月 李宗平 杨旭 张烨 QI Yan;LI Yue;LI Zongping;YANG Xu;ZHANG Ye(Department of Neurosurgery,Mianyang Central Hospital,Mianyang Hospital,School of Medicine,University of Electronic Science and Technology of China,Mianyang 621000,Sichuan,China)

机构地区：[1]电子科技大学医学院附属绵阳医院·绵阳市中心医院神经外科,四川绵阳621000

出　　处：《西部医学》2022年第10期1547-1551,共5页Medical Journal of West China

基　　金：四川省医学科研课题(S16042)。

摘　　要：目的探讨囊性脑膜瘤的临床特点及显微手术后继发癫痫的危险因素。方法纳入2018年2月~2021年4月绵阳市中心医院收治的105例囊性脑膜瘤患者的基线资料,行回顾性分析,将患者显微术后发生癫痫者纳入发生组(55例),未发生癫痫者纳入未发生组(50例)。记录并对比两组患者基线资料,纳入可能影响囊性脑膜瘤患者显微术后发生癫痫的多因素,采用多元Logistic回归分析囊性脑膜瘤患者显微术后继发癫痫的危险因素。结果纳入的患者以头痛为主要表现占46.67%,其次四肢无力、头痛伴四肢无力、癫痫症状表现突出,分别占17.14%、12.38%、12.38%。患者显微术后发生癫痫者占比52.38%,未发生癫痫占比47.62%;两组患者年龄、病灶位置、肿瘤直径、肿瘤切除情况、瘤腔出血、术中皮层或血管损伤情况对比,差异有统计学意义(P<0.05);Logistic回归模型多因素分析结果显示,年龄、病灶位置、肿瘤直径、围术期预防用药、肿瘤切除情况、瘤腔出血、术中皮层或血管损伤情况均是导致囊性脑膜瘤患者显微术后发生癫痫的影响因素(OR>1,P<0.05)。结论年龄、病灶位置、肿瘤直径、肿瘤切除情况、瘤腔出血、术中皮层或血管损伤情况均与囊性脑膜瘤患者显微术后发生癫痫情况密切相关,临床治疗囊性脑膜瘤患者时,针对合并上述危险因素的囊性脑膜瘤患者,进行提前干预,旨在降低囊性脑膜瘤患者术后癫痫发生风险,促进良性预后。Objective To observe the clinical characteristics of cystic meningioma and risk factors for epilepsy secondary to microsurgery,and provide a scientific reference basis for clinical disease treatment and improvement of patient prognosis.Methods The baseline data of 105 patients with cystic meningioma admitted to Mianyang Central Hospital from February 2018 to April 2021 were included in the retrospective analysis.Patients with epilepsy after microsurgery were included in the development group(55 cases),and those without epilepsy were included in the non-development group(50 cases).Recorded and compared two groups of patients with baseline data,may affect the cystic meningioma patients postoperative seizure of microscopic multiple factors,using multivariate Logistic[JP+1]regression analysis of cystic meningioma microscopic surgery in patients with secondary epilepsy risk factors.Results After analyzing the clinical characteristics of the 105 patients with cystic meningioma enrolled,the results showed that the patients especially had headache as the main manifestation accounting for 46.67%,followed by weakness of extremities,headache with weakness of extremities,and epilepsy symptoms with prominent performance,accounting for 17.14%,12.38%,and 12.38%,respectively.The 105 patients with cystic meningioma enrolled in the group had 55 cases of epilepsy after microsurgery,accounting for 52.38%(55/105),which were included in the occurrence group,and 50 cases without epilepsy,accounting for 47.62%(50/105),which were included in the non-occurrence group.The age,location of the lesion,preoperative epilepsy history,tumor diameter,perioperative prophylaxis,tumor resection,tumor cavity bleeding,intraoperative Age,lesion location,preoperative epilepsy history,tumor diameter,perioperative prophylaxis,tumor resection,tumor cavity bleeding,and intraoperative cortical or vascular injury were used as independent variables and assigned values,and whether epilepsy occurred after microsurgery in patients with cystic meningioma was used a

关 键 词：囊性脑膜瘤 临床特点 显微手术 癫痫 影响因素 

分 类 号：R739.41[医药卫生—肿瘤]