儿童神经母细胞瘤骨髓转移机制的研究进展  

Research advance in bone marrow metastasis in children′s neuroblastoma

作　　者：王李慧(综述) 邵静波(审校)[1] Wang Lihui;Shao Jingbo(Department of Hematology/Oncology,Shanghai Children′s Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200040,China)

机构地区：[1]上海市儿童医院,上海交通大学医学院附属儿童医院血液肿瘤科,200040

出　　处：《国际儿科学杂志》2022年第8期505-509,共5页International Journal of Pediatrics

摘　　要：神经母细胞瘤(neuroblastoma,NB)是婴幼儿最常见的颅外实体肿瘤,约50%的患者在确诊前已发生广泛转移,可转移至骨髓、骨、淋巴结、眼眶、肝脏和皮肤等部位,骨髓是NB最常见的转移及复发部位。NB患儿一旦发生转移或复发,其生存率会明显降低。NB骨髓转移的机制尚未阐明,肿瘤细胞的耐药性、骨髓微环境的相互作用、细胞信号通路的调控等,可能对肿瘤细胞的骨髓转移起到重要调节作用。该文对NB骨髓转移机制的研究进展进行综述,以更好地理解NB与骨髓微环境之间的作用机制,为患者的诊治提供新思路。Neuroblastoma is the most common extracranial solid tumor for infants and young children.About 50%of patients have extensive metastasis before diagnosis,and the neuroblastoma can metastasize to bone marrow,bone,lymph node,orbit,liver and skin.Bone marrow is the most common site of neuroblastoma metastasis and recurrence.Once neuroblastoma metastasize or relapse,their survival rate will reduce significantly.The mechanism of neuroblastoma bone marrow metastasis has not been elucidated.The drug resistance of tumor cells,the interaction of bone marrow microenvironment,and the regulation of cell signaling pathways may play important roles in regulating tumor cell bone marrow metastasis.This review summarizes the research progress of bone marrow metastasis in neuroblastoma,which helps us to better understand the mechanism of interaction between neuroblastoma and the bone marrow microenvironment,and to provide new ideas for the diagnosis and treatment of patients.

关 键 词：儿童 神经母细胞瘤 骨髓转移 癌症干细胞 骨髓微环境 信号通路 

分 类 号：R739.4[医药卫生—肿瘤]