后程立体定向放射治疗联合IMRT治疗局部非小细胞肺癌的效果  

Effect of Stereotactic Body Radiotherapy Combined with IMRT in the Treatment of Local Non-small Cell Lung Cancer

作　　者：张喜琴 谢伟煌 ZHANG Xiqin;XIE Weihuang(Xingning People’s Hospital,Xingning 514500,China)

机构地区：[1]兴宁市人民医院,广东兴宁514500

出　　处：《中外医学研究》2022年第26期120-123,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究后程立体定向放射治疗(SBRT)联合适形调强放射治疗(IMRT)对局部非小细胞肺癌(NSCLC)的影响。方法:选取2016年10月-2017年10月在兴宁市人民医院接受治疗的64例局部NSCLC患者。根据随机数字表法将其分为对照组及观察组,各32例。对照组给予IMRT,观察组则在对照组的基础上加用SBRT。比较两组临床疗效、并发症,治疗后1、2、3年生存率,治疗前后生活质量及体能状况。结果:治疗后,观察组总有效率、局部控制率均高于对照组,临床疗效优于对照组(P<0.05)。治疗期间,两组并发症发生率比较差异无统计学意义(P>0.05)。治疗后随访3年,观察组失访2例,对照组失访3例。观察组治疗后1、2、3年生存率均高于对照组(P<0.05)。治疗后,两组癌症患者生存质量通用量表(FACT-G)、卡氏评分表(KPS)评分均有上升,且观察组FACT-G、KPS评分均高于对照组(P<0.05)。结论:SBRT联合IMRT治疗局部NSCLC,可增强治疗效果,提高生存率及生活质量,安全性好,值得临床推广使用。Objective:To explore the effect of stereotactic body radiotherapy (SBRT) combined with intensity modulated radiotherapy (IMRT) in the treatment of local non-small cell lung cancer (NSCLC).Method:A total of 64 patients with local NSCLC who were treated in Xingning People’s Hospital from October 2016 to October 2017 were selected.According to the random number table method,they were divided into control group and observation group,32 cases in each group.The control group was given the IMRT,while the observation group added the SBRT on the basis of the control group.The clinical efficacy,complications,the survival rate at 1,2 and 3 years after treatment,quality of life and physical condition before and after treatment were compared between the two groups.Result:After treatment,the total effective rate and local control rate of the observation group were higher than those of the control group,and the clinical effect was better than that of the control group (P<0.05).During treatment,there was no significant difference in the incidence of complications between the two groups (P>0.05).Follow up for 3 years after treatment,2 cases in the observation group were lost to follow-up,and 3 cases in the control group were lost to follow-up.The survival rate of the observation group at 1,2 and 3 years after treatment were higher than those of the control group (P<0.05).After treatment,the scores of functional assessment of cancer therapy-general (FACT-G) and Karnofsky performance status (KPS) of both groups increased,and the scores of FACT-G and KPS in the observation group were higher than those in the control group (P<0.05).Conclusion:SBRT combined with IMRT in the treatment of local NSCLC can enhance the treatment effect,improve the survival rate and quality of life,and have good safety.It is worthy of clinical promotion and use.

关 键 词：后程立体定向放射治疗 适形调强放射治疗 局部非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]