血栓弹力图、纤维蛋白原及D-二聚体对肺癌患者凝血功能的临床价值分析  

Analysis of the Clinical Value of Thromboelastogram,Fibrinogen and D-dimer on the Coagulation Function of Patients with Lung Cancer

作　　者：吴莉春[1] WU Lichun(The Second Hospital of Sanming,Yong’an 366000,China)

机构地区：[1]三明市第二医院,福建永安366000

出　　处：《中外医学研究》2022年第25期72-75,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨血栓弹力图(TEG)联合纤维蛋白原(FIB)及D-二聚体(D-D)对肺癌患者凝血功能评估的临床应用价值。方法:选择2019年10月-2021年9月三明市第二医院收治的首次确诊的98例肺癌患者作为研究组,同时随机挑取同期本院体检的80例健康人作为对照组,比较两组的TEG各指标[凝血因子反应时间(R)、纤维蛋白聚合时间(K)、纤维蛋白聚合功能(Angle)、血小板聚集功能(MA)、凝血状态综合指数(CI)]、FIB及D-D的检测结果。结果:与对照组相比,研究组TEG水平中的R、K值均显著低,而Angle角、MA、CI、FIB和D-D值均显著高,差异有统计学意义(P<0.05)。Ⅲ~Ⅳ期肺癌患者的R值和K值低于Ⅰ~Ⅱ期肺癌患者,Angle角、MA、CI、FIB及D-D值均高于Ⅰ~Ⅱ期肺癌患者,差异有统计学意义(P<0.05)。有淋巴结转移的肺癌患者的R值和K值低于无淋巴结转移的肺癌患者,Angle角、MA、CI、FIB及D-D值高于无淋巴结转移的肺癌患者,差异有统计学意义(P<0.05)。肺癌稳定及进展组的R、K值较肺癌缓解组显著低,而Angle角、MA、CI、FIB及D-D值较肺癌缓解组显著高,差异有统计学意义(P<0.05)。结论:肺癌患者的凝血功能存在异常,处于高凝状态,而且与预后存在一定的关系,利用TEG、FIB和D-D完善对肺癌患者凝血功能监测有利于对患者早干预早治疗,降低血栓形成风险,为临床上提供一定的参考依据。Objective:To explore the clinical application value of thromboelastogram(TEG)combined with fibrinogen(FIB)and D-dimer(D-D)in the evaluation of coagulation function in patients with lung cancer.Method:A total of 98 patients with lung cancer who were diagnosed for the first time in the Second Hospital of Sanming from October 2019 to September 2021 were selected as the study group.At the same time,a total of 80 healthy people from the physical examination center of our hospital were randomly selected as the control group.The TEG indexes[coagulation factor reaction time(R),fibrin aggregation time(K),fibrin aggregation function(Angle),platelet aggregation function(MA),coagulation state composite index(CI)],FIB and D-D test result of the two groups were compared.Result:Compared with the control group,the R and K values in the TEG level of the study group were significantly lower,while the Angle angle,MA,CI,FIB and D-D values all significantly higher,and the differences were statistically significant(P<0.05).The R and K values of patients with stageⅢ-Ⅳlung cancer were lower than those of patients with stageⅠ-Ⅱlung cancer,and the Angle angle,MA,CI,FIB and D-D values were all higher than those of patients with stageⅠ-Ⅱlung cancer,and the differences were statistically significant(P<0.05).The R and K values of lung cancer patients with lymph node metastasis were lower than those of lung cancer patients without lymph node metastasis,and the Angle angle,MA,CI,FIB and D-D values were higher than those of lung cancer patients without lymph node metastasis,and the differences were statistically significant(P<0.05).The R value and K value in the stable and progressing lung cancer group were significantly lower than those in the lung cancer remission group,while the Angle angle,MA,CI,FIB and D-D values were significantly higher than those in the lung cancer remission group,and the differences were statistically significant(P<0.05).Conclusion:Patients with lung cancer have abnormal coagulation function and are in a hyp

关 键 词：肺癌 凝血功能 血栓弹力图 纤维蛋白原 D-二聚体 

分 类 号：R734.2[医药卫生—肿瘤]