血浆置换联合常规治疗对ICU重症胰腺炎血清淀粉酶、炎症因子及胰腺微循环的影响  

Effect of Plasma Exchange Combined with Conventional Treatment on Serum Amylase,Inflammatory Factors and Pancreatic Microcirculation Index in ICU Patients with Severe Pancreatitis

作　　者：黄玄曦 HUANG Xuanxi(Union Hospital Affiliated to Fujian Medical University,Fuzhou 350001,China)

机构地区：[1]福建医科大学附属协和医院,福建福州350001

出　　处：《中外医学研究》2022年第25期127-130,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨血浆置换联合常规治疗ICU重症胰腺炎对其血清淀粉酶、炎症因子及胰腺微循环指标等指标的作用。方法:以2019年6月-2021年12月福建医科大学附属协和医院收治的ICU重症胰腺炎患者50例为研究对象,以随机数字表法按1∶1分为观察组与对照组,每组25例。对照组予以常规治疗,观察组在对照组的基础上联合血浆置换。观察并对比治疗前后两组患者血清淀粉酶、炎症因子及胰腺微循环指标。结果:治疗前,两组血清淀粉酶(serum amylase,S-Amy)、C反应蛋白(C-reactive protein,CRP)、白介素-6(interleukin-6,IL-6)、降钙素原(procalcitonin,PCT)、血流量(blood flow,BF)、血流容积(blood volume,BV)比较,差异无统计学意义(P>0.05);治疗1周后,两组S-Amy、CRP、IL-6、PCT低于治疗前,且观察组低于对照组(P<0.05);治疗1周后,两组BF、BV高于治疗前,且观察组高于对照组(P<0.05)。结论:血浆置换联合常规治疗能够降低ICU重症胰腺炎患者血清淀粉酶水平,减少炎症因子的同时,改善胰腺微循环指标,有利于疾病转归。Objective:To study the effect of plasma exchange combined with conventional treatment on serum amylase(S-Amy),inflammatory factors and pancreatic microcirculation index in ICU patients with severe pancreatitis.Method:From June 2019 to December 2021,50 patients in Union Hospital Affiliated to Fujian Medical University were selected as the research objects,and they were divided into observation group and control group by random table method according to 1∶1,25 cases in each group.The control group received conventional treatment,and the observation group received plasma exchange on the basis of the control group.S-Amy,inflammatory factors and pancreatic microcirculation indexes were observed and compared between the two groups before and after treatment.Result:Before treatment,there were no significant differences in S-Amy,C-reactive protein(CRP)and interleukin-6(IL-6),procalcitonin(PCT),blood flow(BF)and blood volume(BV)between the two groups(P>0.05).After 1 week of treatment,S-Amy,CRP,IL-6 and PCT of the two groups were lower than those before treatment,and the indexes in the observation group were lower than those of the control group(P<0.05).After 1 week of treatment,BF and BV in the two groups were higher than those before treatment,and which in the observation group were higher than those in the control group(P<0.05).Conclusion:Plasma exchange combined with conventional treatment can reduce the blood amylase level in ICU severe pancreatitis,which can reduce inflammatory factors and improve the pancreatic microcirculation index,which is conducive to the disease outcome.

关 键 词：血浆置换 ICU重症胰腺炎 血清淀粉酶 炎症因子 胰腺微循环 

分 类 号：R576[医药卫生—消化系统]