常规小剂量化疗治疗口腔癌临床疗效及安全性研究  

Study on the clinical efficacy and safety of conventional low-dose chemotherapy in the treatment of oral cancer

作　　者：任晗 Ren Han(Department of Orthodontics,Mouping District Hospital of Yantai City,Yantai,Shandong,264100,China)

机构地区：[1]烟台市牟平区口腔医院,山东烟台264100

出　　处：《中国医学文摘（耳鼻咽喉科学）》2022年第5期72-74,共3页Chinese Medical Digest(Otorhinolaryngology)

摘　　要：目的研讨对口腔癌患者实施常规小剂量化疗治疗的疗效及安全性。方法此研究借助回顾性方式展开,选择我院2017年2月~2018年9月内50例口腔癌患者,其中对照组(23例,单纯手术治疗)和观察组(27例,联合常规小剂量化疗);观察近期疗效、治疗安全性以及患者生存情况。结果观察组近期疗效高达92.59%,不良反应发生率仅为3.70%,对照组分别为65.21%和26.0%,观察组近期疗效显著且治疗安全性较高,治疗后患者PES和OS较长,生存情况较好,两组数据对比,P<0.05。结论对接受手术治疗的口腔癌患者,联合常规小剂量化疗效果显著,可提高近期疗效并确保治疗安全性,继而改善患者生存情况。Objective To study the efficacy and safety of conventional low-dose chemotherapy for patients with oral cancer.Methods This study was carried out in a retrospective manner,selecting 50 patients with oral cancer in our hospital from February 2017 to September 2018,including the control group(23 cases,surgical treatment)and the observation group(27 cases,combined with routine small Dosage chemotherapy);observe the short-term efficacy,treatment safety,and patient survival.Results The short-term curative effect of the observation group was as high as 92.59%,and the adverse reaction rate was only 3.70%.The control group was 65.21% and 26.0%,respectively.The observation group had significant short-term curative effect and high treatment safety.After treatment,the patients had longer PES and OS.The survival situation is better,the data of the two groups are compared,P<0.05.Conclusion For oral cancer patients undergoing surgical treatment,the combination of conventional low-dose chemotherapy has a significant effect,which can improve the short-term efficacy and ensure the safety of treatment,and then improve the survival of patients.

关 键 词：口腔癌 小剂量化疗 近期疗效 治疗安全性 生存情况 

分 类 号：R73[医药卫生—肿瘤]