老年男性维生素D与髋部肌肉含量的关系  

Correlation between vitamin D and muscle content of the hip in elderly men

作　　者：孙婧[1] 杨帆[1] 杨立[1] SUN Jing;YANG Fan;YANG Li(Department of Geriatrics,the Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院老年科,江苏省南京市210008

出　　处：《实用老年医学》2022年第10期1038-1041,共4页Practical Geriatrics

摘　　要：目的探讨老年男性不同年龄段人群中髋部肌肉含量与维生素D之间的关系,为临床肌少症的预防及治疗提供新的观点及依据。方法选取2020~2021年在南京鼓楼医院老年科治疗的60岁及以上男性病人180例,按照年龄分为60~69岁(102例)、70~79岁(45例)、≥80岁(33例)3组。对3组间25羟-维生素D[25(OH)D]水平、腰椎及髋部肌肉组织占比进行比较分析。采用偏相关分析、多元线性回归分析25(OH)D与髋部肌肉的相关性。结果≥80岁组BMI显著低于60~69岁组。随着年龄逐渐增高,髋部肌肉含量逐渐下降(P<0.05)。3组间血清25(OH)D水平差异无统计学意义(P>0.05)。偏相关分析显示,男性髋部肌肉含量与25(OH)D水平在60~69岁组呈正相关(r=0.165,P<0.05),在70~79岁组、80~89岁组中无相关性。多元线性回归显示,25(OH)D水平、腰部肌肉含量与髋部肌肉含量呈正相关(B=0.069,0.335,P<0.05),BMI与髋部肌肉含量呈负相关(B=-0.326,P<0.05)。结论在60~69岁老年男性中,血清25(OH)D水平的降低,对髋部肌肉含量的影响明显,需注意维生素D的补充,以避免肌肉和骨量的减少。Objective To explore the association between the serum level of 25-hydroxyvitamin D(25(OH)D)]and the muscle content of hip in the elderly men with different age,and to provide a new viewpoint for the prevention of sarcopenia.Methods The clinical data of 180 elderly men in Department of Geriatrics,Nanjing Drum Tower Hospital from January 2020 to October 2021 were retrospectively analyzed.Local muscle content of the hip and waist were measured using dual-energy X-ray absorptiometry(DXA).The data of the muscle mass ratio around the waist and hip were collected according to the local BMD model.The subjects were divided into three groups according to the age(60-69 years group,70-79 years group and≥80 years group).The relationship between vitamin D and local muscle content was analyzed using partial correlation analysis and multiple linear regression.Results With the increase of age,there were significant decreases in muscle content of the hip and BMI(P<0.05).There were no significant differences in the serum level of 25(OH)D and the muscle content of the waist between the three groups.There was a positive correlation between the serum level of 25(OH)D and the muscle content of the hip in 60-69 years group(r=0.165,P<0.05).The results of multiple linear regression analysis showed that the serum level of 25(OH)D and waist muscle content were positively correlated with hip muscle content(B=0.069,0.335,P<0.05),and BMI was negatively correlated with hip muscle content(B=-0.326,P<0.05).Conclusions In the elderly men aged 60-69 years old,the decrease of serum level of 25(OH)D has a significant effect on muscle content of the hip,and supplementing vitamin D is helpful to reduce the incidence of sarcopenia and osteoporosis.

关 键 词：老年男性 维生素D 肌肉含量 相关性 

分 类 号：R153.3[医药卫生—营养与食品卫生学]