Characterising acute ischaemic stroke thrombi:insights from histology,imaging and emerging impedance-based technologies  

作　　者：Smita Patil Jean Darcourt Pierluca Messina Franz Bozsak Christophe Cognard Karen Doyle 

机构地区：[1]CÚRAM,SFI Research Centre for Medical Devices,National University of Ireland Galway,Galway,Ireland [2]Neuroradiology,CHU de Toulouse,Toulouse,France [3]Sensome,Massy,France [4]Physiology,National University of Ireland Galway,Galway,Ireland

出　　处：《Stroke & Vascular Neurology》2022年第4期353-363,共11页卒中与血管神经病学（英文）

基　　金：funded by European Regional Development Fund(13/RC/2073_2);Sensome(No grant number),Science Foundation Ireland(13/RC/2073_2).

摘　　要：Treatment of acute ischaemic stroke(AIS)focuses on rapid recanalisation of the occluded artery.In recent years,advent of mechanical thrombectomy devices and new procedures have accelerated the analysis of thrombi retrieved during the endovascular thrombectomy procedure.Despite ongoing developments and progress in AIS imaging techniques,it is not yet possible to conclude definitively regarding thrombus characteristics that could advise on the probable efficacy of thrombolysis or thrombectomy in advance of treatment.Intraprocedural devices with dignostic capabilities or new clinical imaging approaches are needed for better treatment of AIS patients.In this review,what is known about the composition of the thrombi that cause strokes and the evidence that thrombus composition has an impact on success of acute stroke treatment has been examined.This review also discusses the evidence that AIS thrombus composition varies with aetiology,questioning if suspected aetiology could be a useful indicator to stroke physicians to help decide the best acute course of treatment.Furthermore,this review discusses the evidence that current widely used radiological imaging tools can predict thrombus composition.Further use of new emerging technologies based on bioimpedance,as imaging modalities for diagnosing AIS and new medical device tools for detecting thrombus composition in situ has been introduced.Whether bioimpedance would be beneficial for gaining new insights into in situ thrombus composition that could guide choice of optimum treatment approach is also reviewed.

关 键 词：throm ACUTE IMPEDANCE 

分 类 号：R743.3[医药卫生—神经病学与精神病学]