Crosstalk between bone and other organs  

作　　者：Wanqiong Yuan Chunli Song 

机构地区：[1]Department of Orthopedics,Peking University Third Hospital,Beijing,China [2]Beijing Key Laboratory of Spinal Disease,Beijing,China [3]Engineering Research Center of Bone and Joint Precision Medicine,Beijing,China [4]Department of Orthopedics,Peking University Third Hospital,No.49,North Garden Road,Haidian District,Beijing 100919,China

出　　处：《Medical Review》2022年第4期331-348,共18页医学评论（英文）

基　　金：supported by the National key research and development program(2020YFC2009004,2021YFC2501700);National Natural Science Foundation of China(81874010)and PKU-Baidu Fund(2020BD014).

摘　　要：Bone has long been considered as a silent organ that provides a reservoir of calcium and phosphorus,traditionally.Recently,further study of bone has revealed additional functions as an endocrine organ connecting systemic organs of the whole body.Communication between bone and other organs participates in most physiological and pathological events and is responsible for the maintenance of homeostasis.Here,we present an overview of the crosstalk between bone and other organs.Furthermore,we describe the factors mediating the cross-talk and review the mechanisms in the development of potential associated diseases.These connections shed new light on the pathogenesis of systemic diseases and provide novel potential targets for the treatment of systemic diseases.

关 键 词：BONE CROSSTALK endocrine organs OSTEOCALCIN osteokines receptor activator for nuclear factor-κB ligand 

分 类 号：R68[医药卫生—骨科学]