OSTEOCALCIN

作品数：53被引量：214H指数：8
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相关领域：医药卫生更多>>
相关作者：李娜石晓征黄晓巍韩冬李晓华更多>>
相关机构：长春中医药大学南方医科大学第三附属医院成都中医药大学哈尔滨医科大学更多>>
相关期刊：《Journal of Animal Science and Biotechnology》《Journal of Wuhan University of Technology(Materials Science)》《Chinese Journal of Traumatology》《Journal of Diabetes Mellitus》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划吉林省科技发展计划基金南京医科大学校科研和教改项目更多>>
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Association of bone turnover biomarkers with severe intracranial and extracranial artery stenosis in type 2 diabetes mellitus patients被引量：1
《World Journal of Diabetes》2023年第5期594-605,共12页Si-Cong Si Wei Yang Hong-Yu Luo Yi-Xin Ma Huan Zhao Jia Liu 
Supported by Beijing Municipal Hospital Management Center“Cultivation Plan”,No.PX2022032.
BACKGROUND Intracranial and extracranial artery stenosis is associated with cerebral infarction.Vascular calcification and atherosclerosis are the main causes of stenosis and major risk factors for cardiovascular and ...
关键词：Bone turnover biomarkers Type 2 diabetes mellitus OSTEOCALCIN C-terminal cross-linked telopeptide of type I collagen Procollagen type I N-peptide Intracranial and extracranial artery stenosis 
强筋合剂对骨质疏松大鼠治疗及相关基因ALP、Osteocalcin、Runx-2表达的调节作用被引量：1
《浙江中医杂志》2022年第11期784-787,共4页王青华 龚卫月 沈云方 谢海霞 蒋雪嫣 胡钧 
湖州市科技局公益项目强筋合剂对骨质疏松大鼠治疗及相关基因ALP,Osteocalcin,Runx-2表达的调节作用,编号:2018GYB63;浙江省中医药科技计划项目基于新型医用高分子材料为辅料的加味口疮散的研制与药效学研究,编号:2022ZA168。
目的:探讨强筋合剂对骨质疏松的治疗作用及碱性磷酸酶(Alkaline Phosphatase,ALP)、骨钙素(Osteocalcin)和Runt相关转录因子2(Runt-related transcription factor 2,Runx-2)表达的影响。方法:以去卵巢SD大鼠作为模型,随机分为假手术组...
关键词：强筋合剂 骨质疏松 血清碱性磷酸酶 骨钙素 Runx-2 大鼠 
Crosstalk between bone and other organs被引量：1
《Medical Review》2022年第4期331-348,共18页Wanqiong Yuan Chunli Song 
supported by the National key research and development program(2020YFC2009004,2021YFC2501700);National Natural Science Foundation of China(81874010)and PKU-Baidu Fund(2020BD014).
Bone has long been considered as a silent organ that provides a reservoir of calcium and phosphorus,traditionally.Recently,further study of bone has revealed additional functions as an endocrine organ connecting syste...
关键词：BONE CROSSTALK endocrine organs OSTEOCALCIN osteokines receptor activator for nuclear factor-κB ligand 
Vitamin K alleviates bone calcium loss caused by Salmonella Enteritidis through carboxylation of osteocalcin被引量：1
《Journal of Animal Science and Biotechnology》2021年第4期1572-1581,共10页Yaojun Liu Rainer Mosenthin Lihong Zhao Jianyun Zhang Cheng Ji Qiugang Ma 
supported by the National Science Foundation of China(Grant No.31772627);a Special Fund for China Agricultural Research System program(CARS-40-K08);the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation,328017493/GRK 2366);National Key Research and Development Program of China(2017YFD0500500);National Science Foundation of China(Grant No.31772627);was funding for the design of the study and collect sample.A Special Fund for China Agricultural Research System program(CARS-40-K08)was funding for writing the manuscript;Deutsche Forschungsgemeinschaft(DFG,German Research Foundation,328017493/GRK 2366);National Key Research and Development Program of China(2017YFD0500500)were funding for analysis the sample.
Background:The present study aimed at evaluating the effect of vitamin K(VK)supplementation on bone health of laying hens challenged by Salmonella Enteritidis.Methods:A total of 8032-week-old double negative salmonell...
关键词：CALCIUM Laying hen Salmonella Enteritidis Vitamin K 
Decarboxylated osteocalcin,a possible drug for type 2 diabetes,triggers glucose uptake in MG63 cells被引量：2
《World Journal of Diabetes》2021年第7期1102-1115,共14页Shi Jin Xiao-Cen Chang Jing Wen Jing Yang Na Ao Ke-Ying Zhang Lin-Na Suo Jian Du 
Supported by Provincial Science and Technology Department Natural Fund Guidance Project,No.2019-ZD-0774;National Natural Science Foundation of China,No.81470998;Liaoning Ministry of Education,No.LQNK201715;and Liaoning Provincial Doctor Start up Fund,No.20180540008.
BACKGROUND Uncarboxylated osteocalcin(GluOC)has been reported to improve glucose metabolism,prevent type 2 diabetes,and decrease the severity of obesity in mice with type 2 diabetes.GluOC can increase glucose uptake i...
关键词：Decarboxylated osteocalcin OSTEOBLAST Glucose uptake Glucose transporter 1 Type 2 diabetes 
The mTORC1 complex in pre-osteoblasts regulates whole-body energy metabolism independently of osteocalcin
《Bone Research》2021年第1期109-125,共17页Pawanrat Tangseefa Sally K.Martin Peck Yin Chin James Breen Chui Yan Mah Paul A.Baldock Gary A.Wittert Amanda J.Page Christopher G.Proud Stephen Fitter Andrew C.W.Zannettino 
the National Health and Medical Research Council of Australia(APP1109207,awarded to ACWZ,PMB,and CGP);Australian Research Council(DP160100454,awarded to ACWZ and PMB);Diabetes Australia Research Program(awarded to ACWZ,SF and SM);an Australia Postgraduate Award(PT).
Overnutrition causes hyperactivation of mTORC1-dependent negative feedback loops leading to the downregulation of insulin signaling and development of insulin resistance.In osteoblasts(OBs),insulin signaling plays a c...
关键词：METABOLISM mTORC1 HOMEOSTASIS 
BSP、osteocalcin在骨肿瘤组织中的表达
《世界最新医学信息文摘》2020年第52期156-157,共2页石林 郑学均 郭彬 刘自贵 李秋江 杨帆 
目的探讨骨唾液酸蛋白(Bone sialoprotein,BSP)和骨钙素(osteocalcin,OC)蛋白在骨肿瘤组织中的表达情况及其临床意义。方法收集我院2016年10月至2018年10月经病理科确诊骨肿瘤的30例患者的骨肿瘤组织蜡块以及30例骨软骨骨瘤组织蜡块,通...
关键词：骨肿瘤 骨钙素 骨唾液酸蛋白 BSP 
Uncarboxylated osteocalcin ameliorates hepatic glucose and lipid metabolism in KKAy mice via activating insulin signaling pathway被引量：15
《Acta Pharmacologica Sinica》2020年第3期383-393,共11页Xiao-lin Zhang Ya-nan Wang Lu-yao Ma Zhong-sheng Liu Fei Ye Jian-hong Yang 
This work was supported by the grant for a combined research and teaching program from the College of Life Sciences,University of Chinese Academy of Sciences(KJRH2015-006);We also thank the support of the CAMS Innovation Fund for Medical Sciences(CIFMS-2016-I2M-3-012);the Drug Innovation Major Project(2018ZX09711001-003-005).
Osteocalcin,expressed in osteoblasts of the bone marrow,undergoes post-translational carboxylation and deposits in mineralized bone matrix.A portion of osteocalcin remains uncarboxylated(uncarboxylated osteocalcin,Glu...
关键词：metabolic syn drome uncarboxylated osteocalci n(GluOC) insulin resista NEE HYPERGLYCEMIA DYSLIPIDEMIA NONALCOHOLIC fatty-liver disease(NAFLD) OBESE KKAy mouse 
Laboratory Findings in Twins Suffering from Autism—Case Report
《Journal of Health Science》2019年第4期239-245,共7页Slobodan Dunjic Jovana Pejic Emilija Filipovic Milos Maletic Petar Krakovic Dana Stojicic Milica Lojic Vida Subotic 
Autism refers a wide range of conditions and the most prominent are challenges with social skills, repetitive behaviors, speech disturbances. By now, it is known that there is no one type of autism, but there are many...
关键词：AUTISM OSTEOCALCIN thyroid gland vitamin D OXYTOCIN 
Overexpression of Dlx2 enhances osteogenic differentiation of BMSCs and MC3T3-E1 cells via direct upregulation of Osteocalcin and Alp被引量：22
《International Journal of Oral Science》2019年第2期119-130,共12页Jianfei Zhang Wenbin Zhang Jiewen Dai Xudong Wang Steve Guofang Shen 
supported by grant (81771036) from National Natural Science Foundation of China (to S.G.S.);grant (81741028) from National Natural Science Foundation of China (to J.D.);grant (17410710500) Shanghai International Scientific and Technological Cooperation Projects Laser Micromachine and Vascularization of TCP/PCL Scaffolds (to W.Z.)
Genetic studies have revealed a critical role of Distal-homeobox (Dlx) genes in bone formation,and our previous study showed that Dlx2 overexpressing in neural crest cells leads to profound abnormalities of the cranio...
关键词：BMSCS MC3T3-E1 OSTEOCALCIN 
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