2020—2021年间淄博市张店区孕中期产前唐氏血清筛查风险评估  

Risk Assessment of Antenatal Down's Serum Screening in the Second Trimester of Pregnancy in Zhangdian District, Zibo City from 2020 to 2021

作　　者：许军[1] 王智 朱华 XU Jun;WANG Zhi;ZHU Hua(Health Department,Zibo Maternal and Child Health Hospital,Zibo,Shandong Province,255000 China;Medical Department,Zibo Maternal and Child Health Hospital,Zibo,Shandong Province,255000 China)

机构地区：[1]淄博市妇幼保健院保健部,山东淄博255000 [2]淄博市妇幼保健院医务科,山东淄博255000

出　　处：《中国卫生产业》2022年第17期219-222,共4页China Health Industry

摘　　要：目的探究2020—2021年间淄博市张店区孕中期产前唐氏血清筛查风险情况。方法选取2020年1月—2021年12月期间淄博市张店区所在妇幼保健机构接受产前筛查的总计4520例孕15~20+6周孕妇作为本研究对象,对血清甲胎蛋白、游离β-人绒毛膜促性腺激素、游离雌三醇三联指标进行检测,检测结果结合孕妇年龄、孕周及体质量等因素,采取配套软件进行综合评分评估。结果2020年、2021年筛查出DS高风险人群为101例(6.44%)、120例(4.96%),其中真阳性2020年为0例,2021年为6例,2020年、2021年ONTDs高风险、ES高风险分别为26例(1.66%)、42例(1.74%)、5例(0.32%)、0例(0.00%);筛查随访孕妇中,异常妊娠结局合计为71例,占比1.78%(71/3987),其中流产/胎死宫内、其他并列第一,占比25.35%;≥35周岁孕妇DS、ES、ONTDs筛查高风险性高于<25岁、25~35岁。结论孕中期展开血清学“三联法”能早期筛查出胎儿唐氏综合征,作为一类无创性筛查手段,将其应用于孕期产检中能及时发现缺陷儿,并及早干预降低缺陷儿出生率,提高出生人口素质水平。Objective To explore the risk of antenatal Down's serum screening in the second trimester of pregnancy in Zhangdian District,Zibo City from 2020 to 2021.Methods From January 2020 to December 2021,a total of 4520 pregnant women at 15-20+6 weeks of pregnancy who received prenatal screening in the maternal and child health care institutions in Zhangdian District,Zibo City were selected as the research objects.Serum alpha-fetoprotein,freeβ-human chorionic gonadotropin and free estriol triple indexes were detected.The test results were combined with factors such as maternal age,gestational age,and body weight,and a comprehensive score evaluation is carried out using the supporting software.Results In 2020 and 2021,101 cases(6.44%)and 120 cases(4.96%)of DS high-risk groups were screened.Among them,there were 0 true positive cases in 2020,6 cases in 2021,and 26 cases(1.66%),42 cases(1.74%),5 cases(0.32%),26 cases(1.66%),42 cases(1.74%),5 cases(0.32%),0 cases(0.00%).Among pregnant women who were screened and followed up,a total of 71 cases had abnormal pregnancy outcomes,accounting for 1.78%(71/3987).Among them,miscarriage/intrauterine and others tied for the first place,accounting for 25.35%;the high risk of DS,ES,and ONTDs screening in pregnant women≥35 years old was higher than that of<25 years old and 25-35 years old.Conclusion The"triple method"of serology in the second trimester can detect the fetal Down syndrome early.As a kind of non-invasive screening method,it can be used in the obstetric examination during pregnancy to detect the defective child in time, and early intervention to reduce the birth rate of defects and improve the quality of the birth population.

关 键 词：孕中期 产前筛查 唐氏综合征 淄博 血清 风险评估 

分 类 号：R19[医药卫生—卫生事业管理]