Trilateral interaction between innervation,leukocyte,and adventitia:a new driver of atherosclerotic plaque formation  

作　　者：Yahya Sohrabi Holger Reinecke Oliver Soehnlein 

机构地区：[1]Department of Cardiology I—Coronary and Peripheral Vascular Disease,Heart Failure,University Hospital Münster,Westfälische Wilhelms-Universität,Münster,Germany [2]Institutes of Molecular Genetics of the Czech Academy of Sciences,Prague,Czechia [3]Institute of Experimental Pathology(ExPat),Center for Molecular Biology of Inflammation(ZMBE),University Hospital Münster,Westfälische Wilhelms-Universität,Münster,Germany [4]Department of Physiology and Pharmacology(FyFa),Karolinska Institutet,Stockholm,Sweden

出　　处：《Signal Transduction and Targeted Therapy》2022年第8期2670-2672,共3页信号转导与靶向治疗（英文）

基　　金：Open Access funding enabled and organized by Projekt DEAL;Y.S.would like to acknowledge European network for research in vascular ageing(COST Action 18216);Dr.Robert Pfleger Foundation(grant ZUW80298);O.S.receives support from the Deutsche Forschungsgemeinschaft(SFB914 B8,SFB1009 A13,SFB1123 A6,SFB/TRR332 A2&Z1,OR465/1-1);the Else Kröner Fresenius Stiftung,the Leducq Foundation and the IZKF of the Medical Faculty of the University of Münster.

摘　　要：A recent study by Mohanta et al.describes a new understanding of neuroimmune interactions in atherosclerosis.While atherosclerotic plaques are not innervated,ablating the sympathetic innervation to these regions attenuated atherosclerosis,suggesting a potential novel therapeutic strategy.Atherosclerosis continues to be the leading cause of death in industrialized countries due to its complications such as acute myocardial infarction or stroke.The disease is the result of a complex process,consisting of sub-endothelial lipid retention,immune cell migration,proteolytic injury,altogether leading to a chronic inflammatory responses in the wall of large arteries and ultimately plaque development.2 The inner layer of the blood vessels is not innervated and hence the nervous system connects with the vessel through its most outer layer,the lamina adventitia,hereby controlling important functions including arterial blood pressure.Beyond such homeostatic control of vessel function,increasing evidence demonstrates that activation of the sympathetic nervous system can modulate the degree of arterial inflammation.

关 键 词：SYMPATHETIC ACUTE hence 

分 类 号：R543.5[医药卫生—心血管疾病]