研磨法制备金属有机框架材料的新进展  

Progress in preparation of metal-organic framework materials by grinding

作　　者：张珂 屈小虎 朱元军[2] 林建英 赵志换 樊惠玲[3] ZHANG Ke;QU Xiaohu;ZHU Yuanjun;LIN Jianying;ZHAO Zhihuan;FAN Huiling(College of Biomedical Engineering,Taiyuan University of Technology,Taiyuan 030024,Shanxi,China;School of Pharmaceutical Science,Peking University,Beijing 100191,China;Institute of Coal Chemical Industry,Taiyuan University of Technology,Taiyuan 030024,Shanxi,China)

机构地区：[1]太原理工大学生物医学工程学院,山西太原030024 [2]北京大学药学院,北京100191 [3]太原理工大学煤化工研究所,山西太原030024

出　　处：《化工进展》2022年第10期5465-5473,共9页Chemical Industry and Engineering Progress

基　　金：国家自然科学基金(21878209);山西省重点研发计划(201903D321100)。

摘　　要：金属有机框架材料是由金属离子/团簇和具有一定刚性结构的有机配体通过配位键连接而成的多孔晶体材料,具有多孔、比表面积大、结构多样、表面易修饰等特点,在能源、化工、医药领域具有广泛的应用。机械化学合成法是指通过机械能诱导化学反应的方法,由于其绿色环保、耗时短、效率高、应用范围广、副反应少的特点近年来受到广泛关注,在制备金属有机框架材料方面同样表现出显著的优势。研磨法是机械化学合成法中重要的一种。为了解生物金属骨架材料的机械化学法合成概况及最新进展,本文介绍了研磨法制备金属有机框架材料的经典案例,尤其着重介绍了应用于医药领域的金属有机框架材料的合成,研究进展表明研磨法是一种绿色高效的合成方法,为金属有机框架材料在医药领域的广泛应用提供了可能,具有良好的发展前景。Metal-organic framework is a porous crystal material composed of metal ions/clusters and organic ligands with a certain rigid structure connected by coordination bonds. It has many advantages,such as porous, large specific surface area, various structure and easy modification. It is widely used in energy, chemical industry and medicine. Mechanochemical synthesis is a method of chemical reaction induced by mechanical energy. It has been widely concerned in recent years because of its green, short time-consuming, high efficiency, wide application range and few side reactions. Mechanochemical synthesis also shows significant advantages in the preparation of metal organic framework materials. In order to have a comprehensive understanding of the latest development of the mechanochemical synthesis of biomaterials, this paper introduces the classic cases of the preparation of metal-organic frameworks by grinding method. Especially, the synthesis of metal-organic framework for biological and medical applications is introduced. The research progress shows that grinding method, which is green and efficient, provides the possibility for the wide application of metal-organic framework materials in the field of medicine and has a good prospect.

关 键 词：机械化学法 制备 金属有机框架 配合物 载体 药物递送 

分 类 号：O6-1[理学—化学]