National Natural Science Foundation of China(Grant No.81573333 and 81503060)
Recombinant tissue plasminogen activator (rPA) has been used as a thrombolytic agent. However, considerable improvements have been done to prolong its plasma half-life (tl/2) and reduce its side effects, such as i...
Natural Science Foundation of China (Grant No.813 02763);Beijing Natural Science Foundation (Grant No.7144218)
In the present study, we investigated anti-thrombotic effects of W007B, a water-soluble derivative of honokiol, with different models both in vitro and in vivo. Rat platelet aggregation was induced by adenosine diphos...
National Natural Science Foundation of China(Grant No.81302763);Beijing Natural Science Foundation(Grant No.7144218)
To explore the effect of multiple pathway intervention in acute cerebral ischemia injury, we prepared a medicine formula (formula 2) consisting of ginsenosides, pueraria flavonoids, ophiopogonis and borneol as a too...
National Technology Graveness Special Purpose Fund(Grant No.2009ZX09301-010)
Recombinant ancylostoma caninum anticoagulant peptide-5 (rAcAP5) has been reported to inhibit thrombin-activatable fibrinolysis inhibitor (TAFIa) activity and have thrombolytic effect. The present study was to scr...
National Technology Graveness Special Purpose Fund (Grant No. 2009zx09301-010)
Ancylostoma anticoagulant peptide 5 (AcAP5) is a strong inhibitor of human coagulation factor Xa (FXa). The N-terminal residues (N40) of AcAP5 contains a domain that could combine with FXa. In order to determine...