ANTITHROMBOSIS

作品数：10被引量：26H指数：3
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相关领域：医药卫生更多>>
相关作者：胡琨朱元军王银叶刘晓岩更多>>
相关机构：北京大学更多>>
相关期刊：《Science China(Life Sciences)》《Regenerative Biomaterials》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金北京市自然科学基金更多>>
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Bioinspired super-hydrophilic zwitterionic polymer armor combats thrombosis and infection of vascular catheters
《Bioactive Materials》2024年第7期493-504,共12页You Ke Haotian Meng Zeyu Du Wentai Zhang Qing Ma Yuting Huang Linxian Cui Yifeng Lei Zhilu Yang 
supported by the National Natural Science Foundation of China (Project 82072072,32261160372,32171326,32371377);the Guangdong Basic and Applied Basic Research Foundation (2022B1515130010,2021A1515111035);Dongguan Science and Technology of Social Development Program (20231800906311,20231800900332).
Thrombosis and infection are two major complications associated with central venous catheters(CVCs),which significantly contribute to morbidity and mortality.Antifouling coating strategies currently represent an effic...
关键词：ANTI-INFECTION ANTITHROMBOSIS Phenol-polyamine SUPER-HYDROPHILICITY Zwitterionic polymers 
Recent progress in functional modification and crosslinking of bioprosthetic heart valves
《Regenerative Biomaterials》2024年第1期1-16,共16页Cheng Zheng Li Yang Yunbing Wang 
supported by National Key Research and Development Programs,China(2022YFB3807305 and 2022YFB3807303);National Natural Science Foundation of China(32071357).
Valvular heart disease(VHD),clinically manifested as stenosis and regurgitation of native heart valve,is one of the most prevalent cardiovascular diseases with high mortality.Heart valve replacement surgery has been r...
关键词：bioprosthetic heart valves MODIFICATION CROSSLINKING anticalcification ANTITHROMBOSIS 
Zwitterionic polymers-armored amyloid-like protein surface combats thrombosis and biofouling被引量：2
《Bioactive Materials》2024年第2期37-51,共15页Xiaohui Mou Wan Miao Wentai Zhang Wenxuan Wang Qing Ma Zeyu Du Xin Li Nan Huang Zhilu Yang 
supported by by the National Natural Science Foundation of China(Project 82202325,82072072,32171326,32261160372);the Guang Dong Basic and Applied Basic Research Foundation(2022B1515130010,2021A1515111035);China Postdoctoral Science Foundation(2022M721524).
Proteins,cells and bacteria adhering to the surface of medical devices can lead to thrombosis and infection,resulting in significant clinical mortality.Here,we report a zwitterionic polymers-armored amyloid-like prote...
关键词：Amyloid-like protein ANTIFOULING ANTITHROMBOSIS SUPER-HYDROPHILICITY Zwitterionic polymers 
Discovery of novel aspartate derivatives as highly potent and selective FXIa inhibitors
《Journal of Chinese Pharmaceutical Sciences》2022年第10期727-737,共11页Ling Zhang Wei Chen Ningning Yao Shuzeng Hou Zhiwei Meng Yi Kong Chenzhong Liao Zhouling Xie 
National Natural Science Foundation of China(Grant No.81803352)。
As a coagulation factor in the intrinsic coagulation pathway,factor XIa(FXIa)is an effective and safe target for the development of antithrombotic drugs.Many small-molecule FXIa inhibitors have been discovered,some of...
关键词：ANTITHROMBOSIS ANTICOAGULANTS Factor XIa Bleeding risk Structure-activity relationship 
Guanxinning tablet inhibits the interaction between leukocyte integrin Mac-1 and platelet GPIbαfor antithrombosis without increased bleeding risk被引量：8
《Chinese Journal of Natural Medicines》2022年第8期589-600,共12页YANG Qin-Qin FANG Ming-Sun TU Jue MA Quan-Xin SHEN Li-Ye XU Yan-Yun CHEN Jie CHEN Min-Li 
Recent studies have showed that thrombosis is closely related to leucocytes involved in immunity.Interfering with the binding of leukocyte integrin Mac-1 and platelet GPIbαcan inhibit thrombosis without affecting phy...
关键词：Thrombosis Guanxinning tablet Phenolic acids Integrin Mac-1 Glycoprotein Ibα 
A botanical medicine dragon’s blood exhibited clinical antithrombosis efficacy similar to low molecular weight heparin被引量：6
《Science China(Life Sciences)》2021年第10期1691-1701,共11页Jiangbin Liang Song Mei Xiangyu Qiao Wei Pan Yan Zhao Shaohui Shi Yaling Zhai Haizhao Wen Guoping Wu Chengyu Jiang 
supported by the National Natural Science Foundation of China(81788101);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2017-I2M-1-009).
Deep vein thrombosis(DVT)is a common complication following traumatic fracture with a 0.5%–1%annual incidence.Low molecular weight heparin(LMWH)is the most commonly used anticoagulation drug for DVT prevention,but tr...
关键词：dragon’s blood low molecular weight heparin deep vein thrombosis TRANSCRIPTOME 
Immobilization of heparin on decellularized kidney scaffold to construct microenvironment for antithrombosis and inducing reendothelialization被引量：1
《Science China(Life Sciences)》2018年第10期1168-1177,共10页Miao Wang Lili Bao Xinyu Qiu Xiaoshan Yang Siying Liu Yuting Su Lulu Wang Bo Liu Qing He Shiyu Liu Yan Jin 
supported by grants from the National Key Research and Development Program of China (2016YFC1101400, 2016YFC1102903);the National Natural Science Foundation of China (31670995, 81470679)
In recent years, rapid development of tissue engineering technology provides possibilities for the construction of artificial tissues or organs. In construction of engineered kidneys, researchers used native decellula...
关键词：DECELLULARIZATION KIDNEY SCAFFOLD ANTITHROMBOSIS REENDOTHELIALIZATION 
Effect of alteplase thrombolysis sequenced by low molecular heparin calcium antithrombosis on the neurological function and serum cytokines in patients with cerebral infarction
《Journal of Hainan Medical University》2017年第8期173-176,共4页Yi-Ping Dan 
Objective:To study the effect of alteplase thrombolysis sequenced by low molecular heparin calcium antithrombosis on the neurological function and serum cytokines in patients with cerebral infarction.Methods:Patients ...
关键词：Acute cerebral infarction ALTEPLASE LOW MOLECULAR HEPARIN Platelet activation Neurological function 
The pyrrolidinoindoline alkaloid Psm2 inhibits platelet aggregation and thrombus formation by affecting PI3K/Akt signaling被引量：7
《Acta Pharmacologica Sinica》2016年第9期1208-1217,共10页Xing-li SU Wen SU Ying WANG Yue-hu WANG Xin MING Yi KONG 
Aim： Psm2, one of the pyrrolidinoindoline alkaloids isolated from whole Selaginella moellendorffii plants, has shown a potent antiplatelet activity. In this study, we further evaluated the antiplatelet effects of Psm...
关键词：Psm2 SELAGINELLACEAE pyrrolidinoindoline alkaloid ANTIPLATELET ANTITHROMBOSIS PI3K/Akt signaling 
Anti-thrombotic effect of W007B,a newly synthesized compound,in vitro and in vivo被引量：2
《Journal of Chinese Pharmaceutical Sciences》2014年第11期760-764,共5页胡琨 刘晓岩 朱元军 张精亮 刘晔 王银叶 
Natural Science Foundation of China (Grant No.813 02763);Beijing Natural Science Foundation (Grant No.7144218)
In the present study, we investigated anti-thrombotic effects of W007B, a water-soluble derivative of honokiol, with different models both in vitro and in vivo. Rat platelet aggregation was induced by adenosine diphos...
关键词：ANTIPLATELET ANTITHROMBOSIS W007B 
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