Bioinspired super-hydrophilic zwitterionic polymer armor combats thrombosis and infection of vascular catheters  

作　　者：You Ke Haotian Meng Zeyu Du Wentai Zhang Qing Ma Yuting Huang Linxian Cui Yifeng Lei Zhilu Yang 

机构地区：[1]Dongguan Key Laboratory of Smart Biomaterials and Regenerative Medicine,The Tenth Affiliated Hospital,Southern Medical University,Dongguan,Guangdong,523000,China [2]School of Materials Science and Engineering,Key Lab of Advanced Technology for Materials of Education Ministry,Southwest Jiaotong University,Chengdu,Sichuan,610031,China [3]Geriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of Chengdu,Department of Cardiology,Chengdu Fifth People’s Hospital(The Second Clinical Medical College,Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine),Chengdu,Sichuan,611137,China [4]The Institute of Technological Science,Wuhan University,Wuhan,430072,China

出　　处：《Bioactive Materials》2024年第7期493-504,共12页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China (Project 82072072,32261160372,32171326,32371377);the Guangdong Basic and Applied Basic Research Foundation (2022B1515130010,2021A1515111035);Dongguan Science and Technology of Social Development Program (20231800906311,20231800900332).

摘　　要：Thrombosis and infection are two major complications associated with central venous catheters(CVCs),which significantly contribute to morbidity and mortality.Antifouling coating strategies currently represent an efficient approach for addressing such complications.However,existing antifouling coatings have limitations in terms of both duration and effectiveness.Herein,we propose a durable zwitterionic polymer armor for catheters.This armor is realized by pre-coating with a robust phenol-polyamine film inspired by insect sclerotization,followed by grafting of poly-2-methacryloyloxyethyl phosphorylcholine(pMPC)via in-situ radical polymerization.The resulting pMPC coating armor exhibits super-hydrophilicity,thereby forming a highly hydrated shell that effectively prevents bacterial adhesion and inhibits the adsorption and activation of fibrinogen and platelets in vitro.In practical applications,the armored catheters significantly reduced inflammation and prevented biofilm formation in a rat subcutaneous infection model,as well as inhibited thrombus formation in a rabbit jugular vein model.Overall,our robust zwitterionic polymer coating presents a promising solution for reducing infections and thrombosis associated with vascular catheters.

关 键 词：ANTI-INFECTION ANTITHROMBOSIS Phenol-polyamine SUPER-HYDROPHILICITY Zwitterionic polymers 

分 类 号：O56[理学—原子与分子物理]