ALTEPLASE

作品数：29被引量：60H指数：4
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相关领域：医药卫生更多>>
相关期刊：《Journal of Hainan Medical University》《China Medical Abstracts(Internal Medicine)》《Journal of Acute Disease》《Journal of Geriatric Cardiology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Intravenous tenecteplase compared with alteplase for minor ischaemic stroke:a secondary analysis of the AcT randomised clinical trial
《Stroke & Vascular Neurology》2024年第6期604-612,共9页Radhika Nair Nishita Singh Mahesh Kate Negar Asdaghi Robert Sarmiento Fouzi Bala Shelagh B Coutts MacKenzie Horn Alexandre Y Poppe Heather Williams Ayoola Ademola Ibrahim Alhabli Faysal Benali Houman Khosravani Gary Hunter Aleksander Tkach Herbert Alejandro Manosalva Alzate Aleksandra Pikula Thalia Field Anurag Trivedi Dar Dowlatshahi Luciana Catanese Ashfaq Shuaib Andrew Demchuk Tolulope Sajobi Mohammed A Almekhlafi Richard H Swartz Bijoy Menon Brian H Buck 
Background In ischaemic stroke,minor deficits(National Institutes of Health Stroke Scale(NIHSS)≤5)at presentation are common but often progress,leaving patients with significant disability.We compared the efficacy an...
关键词：ACUTE MINOR analysis 
Reteplase versus alteplase for acute ischaemic stroke within 4.5 hours(RAISE):rationale and design of a multicentre,prospective,randomised,open-label,blinded-endpoint,controlled phase 3 non-inferiority trial
《Stroke & Vascular Neurology》2024年第5期568-573,共6页Shuya Li Hong-Qiu Gu Hongguo Dai Guozhi Lu Yongjun Wang 
National Natural Science Foundation of China(U20A20358);Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2019-I2M 5-029);Beijing Municipal Science&Technology Commission(No.2221100007422050);National Natural Science Foundation of China(U20A20358);Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2019-I2M 5-029);Beijing Municipal Science&Technology Commission(No.2221100007422050).
Background and purpose Reteplase is the third generation of alternative thrombolytic agent.We hypothesis that reteplase will be non-inferior to alteplase in achieving excellent functional outcome at 90 days among elig...
关键词：centre ENDPOINT random 
Tenecteplase versus alteplase for acute ischaemic stroke:a meta-analysis of phaseⅢrandomised trials
《Stroke & Vascular Neurology》2024年第4期360-366,I0001-I0021,共28页Yunyun Xiong Liyuan Wang Guangshuo Li Kai-Xuan Yang Manjun Hao Shuya Li Yuesong Pan Yongjun Wang 
supported by grants from The National Natural Science Foundation(82171272);Beijing Municipal Science and Technology Committee(Z211100003521019);Beijing Hospitals Authority(PX2022019).
Background Tenecteplase(TNK)was found non-inferior to alteplase in recent clinical trials.We aimed to elucidate the efficacy and safety of TNK versus alteplase for acute ischaemic stroke(AIS).Methods Systematic litera...
关键词：analysis RANDOM PHASE 
Treatment with intravenous alteplase in ischaemic stroke patients with onset time between 4.5 and 24 hours(HOPE):protocol for a randomised,controlled,multicentre study
《Stroke & Vascular Neurology》2024年第3期318-323,I0274-I0282,共15页Zhongyu Luo Ying Zhou Yaode He Shenqiang Yan Zhicai Chen Xuting Zhang Yi Chen Lu-Sha Tong Wansi Zhong Haitao Hu Kemeng Zhang Jiansheng Yang Bruce C V Campbell Min Lou 
HOPE is sponsored and supported by the Second Affiliated Hospital,School of Medicine,Zhejiang University.
Background While intravenous thrombolysis is recommended for patients who had an acute ischaemic stroke(AIS)within 4.5hours of symptom onset,there are few randomised trials investigating the benefits of thrombolysis b...
关键词：patients INTRAVENOUS CENTRE 
Tenecteplase versus alteplase in treatment of acute ST-segment elevation myocardial infarction:A randomized non-inferiority trial被引量：4
《Chinese Medical Journal》2024年第3期312-319,共8页Xingshan Zhao Yidan Zhu Zheng Zhang Guizhou Tao Haiyan Xu Guanchang Cheng Wen Gao Liping Ma Liping Qi Xiaoyan Yan Haibo Wang Qingde Xia Yuwang Yang Wanke Li Juwen Rong Limei Wang Yutian Ding Qiang Guo Wanjun Dang Chen Yao Qin Yang Runlin Gao Yangfeng Wu Shubin Qiao 
supported by the Guangzhou Recomgen Biotech Co.,Ltd.The funder had no role in the design and conduct of the study;collection,management,analysis,and interpretation of the data
Background:A phase II trial on recombinant human tenecteplase tissue-type plasminogen activator(rhTNK-tPA)has previously shown its preliminary efficacy in ST elevation myocardial infarction(STEMI)patients.This study w...
关键词：Thrombolytic therapy rhTNK-tPA Randomized controlled trial ST elevation myocardial infarction 
Acute Cerebral Infarction:A Case Report
《Journal of Cerebrovascular Disease》2023年第4期22-25,共4页Ishara Ruwanthi Thalangama Arachchige 
This case report describes the presentation,diagnosis,and management of a 48-year-old man with acute cerebral infarction of the left fronto-parietal-superior temporal lobe.The patient presented to the local hospital w...
关键词：Ischemic stroke ALTEPLASE Middle cerebral artery Cerebrovascular stenting Non-contrast computed tomography Magnetic resonance angiography 
The efficacy and safety of intravenous alteplase and urokinase in elderly stroke patients:a secondary analysis of INTRECIS study
《China Medical Abstracts(Internal Medicine)》2023年第2期124-125,共2页宁乐馨 
Objective To analyse the efficacy and safety of elderly patients with acute ischemic stroke who underwent intravenous thrombolysis with alteplase(recombinant tissue plasminogen activator,r-tPA)and urokinase(UK)within ...
关键词：INTRAVENOUS UROKINASE PATIENTS 
Early intravenous administration of tirofiban is recommended in patients with acute ischemic stroke treated with alteplase:a meta-analysis
《Aging Communications》2023年第1期12-19,共8页Yan-Chao Huo Lu Yang Wen-Jing Zhou Meng Geng Meng Zhang Wen-Bo Zhao Yao-Ming Xu 
supported by the Natural Science Foundation of Inner Mongolia(No.2021MS08169);the Medical and health Science and Technology Project of Inner Mongolia(No.202201571).
Background:The occurrence of early neurological deterioration following intravenous thrombolysis(IVT)is considered a particularly ominous clinical event and is strongly correlated with poor outcomes.Initiating tirofib...
关键词：acute ischemic stroke tirofiban ALTEPLASE intravenous thrombolysis META-ANALYSIS 
Effect Analysis of Intravenous Thrombolysis with Alpinase Combined with Shuxuening Injection on Acute Ischemic Stroke
《外文科技期刊数据库(文摘版)医药卫生》2022年第10期071-075,共5页LUYe 
Objective: to observe the clinical effect of intravenous thrombolysis with alteplase combined with Shuxuening injection on ischemic stroke. Methods: selected subjects: 90 patients with acute ischemic stroke in the eme...
关键词：intravenous thrombolysis with alteplase Shuxuening injection acute ischemic stroke clinical effec 
Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion被引量：14
《Stroke & Vascular Neurology》2022年第3期190-199,共10页Ximing Nie David Wang Yuehua Pu Yufei Wei Qixuan Lu Hongyi Yan Xin Liu Lina Zheng Jingyi Liu Xinxuan Yang Yarong Ding Dacheng Liu Wanying Duan Zhe Zhang Zhonghua Yang Miao Wen Weibin Gu Xinyi Hou Xinyi Leng Yuesong Pan Zhongrong Miao Liping Liu 
This work was supported by the National Key R&D Program of China(2016YFC1307301);the National Natural Science Foundation of China(81820108012);This study was partially funded by Boehringer Ingelheim China.
Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT...
关键词：ACUTE INTRAVENOUS OCCLUSION 
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