Treatment with intravenous alteplase in ischaemic stroke patients with onset time between 4.5 and 24 hours(HOPE):protocol for a randomised,controlled,multicentre study  

作　　者：Zhongyu Luo Ying Zhou Yaode He Shenqiang Yan Zhicai Chen Xuting Zhang Yi Chen Lu-Sha Tong Wansi Zhong Haitao Hu Kemeng Zhang Jiansheng Yang Bruce C V Campbell Min Lou 

机构地区：[1]Department of Neurology,Zhejiang University School of Medicine Second Affiliated Hospital,Hangzhou,Zhejiang,China [2]Department of Medicine and Neurology,Melbourne Brain Centre at Royal Melbourne Hospital,Parkville,Victoria,Australia

出　　处：《Stroke & Vascular Neurology》2024年第3期318-323,I0274-I0282,共15页卒中与血管神经病学（英文）

基　　金：HOPE is sponsored and supported by the Second Affiliated Hospital,School of Medicine,Zhejiang University.

摘　　要：Background While intravenous thrombolysis is recommended for patients who had an acute ischaemic stroke(AIS)within 4.5hours of symptom onset,there are few randomised trials investigating the benefits of thrombolysis beyond this therapeutic window.Aim To determine whether patients who had an AIS selected with the presence of potentially salvageable tissue on CT perfusion at 4.5–24hours after stroke onset(for stroke with unknown onset time,the midpoint of the time last known to be well and symptom recognition time;for wake-up stroke,the midpoint of the time last known to be well or sleep onset and wake up time)will benefit from intravenous thrombolysis.Design HOPE is a prospective,multicentre,randomised,open-label blinded endpoint trial with the stage of phase III.The treatment allocation employs 1:1 randomisation.The treatment arm under investigation is alteplase with standard therapy,the control arm is standard therapy.Eligibility imaging criteria include ischaemic core volume≤70mL,penumbra≥10mL and mismatch≥20%.Study outcomes The primary outcome is non-disabled functional outcome(assessed as modified Rankin Scale score of 0–1 at 90 days).Discussion HOPE is the first trial to investigate whether intravenous thrombolysis with alteplase offers benefits in patients who had an AIS presenting within 4.5–24hours,which has the potential to extend time window and expand eligible population for thrombolysis therapy.

关 键 词：patients INTRAVENOUS CENTRE 

分 类 号：R743.3[医药卫生—神经病学与精神病学]