Recent progress in functional modification and crosslinking of bioprosthetic heart valves  

作　　者：Cheng Zheng Li Yang Yunbing Wang 

机构地区：[1]National Engineering Research Center for Biomaterials,Sichuan University,Chengdu 610064,China

出　　处：《Regenerative Biomaterials》2024年第1期1-16,共16页再生生物材料（英文版）

基　　金：supported by National Key Research and Development Programs,China(2022YFB3807305 and 2022YFB3807303);National Natural Science Foundation of China(32071357).

摘　　要：Valvular heart disease(VHD),clinically manifested as stenosis and regurgitation of native heart valve,is one of the most prevalent cardiovascular diseases with high mortality.Heart valve replacement surgery has been recognized as golden standard for the treatment of VHD.Owing to the clinical application of transcatheter heart valve replacement technic and the excellent hemodynamic performance of bioprosthetic heart valves(BHVs),implantation of BHVs has been increasing over recent years and gradually became the preferred choice for the treatment of VHD.However,BHVs might fail within 10-15 years due to structural valvular degeneration(SVD),which was greatly associated with drawbacks of glutaraldehyde crosslinked BHVs,including cytotoxicity,calcification,component degradation,mechanical failure,thrombosis and immune response.To prolong the service life of BHVs,much effort has been devoted to overcoming the drawbacks of BHVs and reducing the risk of SVD.In this review,we summarized and analyzed the research and progress on:(i)modification strategies based on glutaraldehyde crosslinked BHVs and(ii)nonglutaraldehyde crosslinking strategies for BHVs.

关 键 词：bioprosthetic heart valves MODIFICATION CROSSLINKING anticalcification ANTITHROMBOSIS 

分 类 号：O63[理学—高分子化学]