Biomarkers in oral immunotherapy  

作　　者：Haitao ZHU Kaifa TANG Guoqiang CHEN Zhongwei LIU 

机构地区：[1]Department of Pediatrics(No.3 Ward),Northwest Women’s and Children’s Hospital,Xi’an,710061,China [2]Department of Urology,the Affiliated Hospital of Guizhou Medical University,Guiyang,550004,China [3]Department of Cardiology,Shaanxi Provincial People’s Hospital,Xi’an,710068,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2022年第9期705-731,共27页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the Talent Training Project of Northwest Women’s and Children’s Hospital(No.2018LQ01);the National Natural Science Foundation of China(No.82070858);the Natural Science Foundation of Shaanxi Province(Nos.2020JQ-941 and 2021JQ-911),China。

摘　　要：Food allergy(FA)is a global health problem that affects a large population,and thus effective treatment is highly desirable.Oral immunotherapy(OIT)has been showing reasonable efficacy and favorable safety in most FA subjects.Dependable biomarkers are needed for treatment assessment and outcome prediction during OIT.Several immunological indicators have been used as biomarkers in OIT,such as skin prick tests,basophil and mast cell reactivity,T cell and B cell responses,allergen-specific antibody levels,and cytokines.Other novel indicators also could be potential biomarkers.In this review,we discuss and assess the application of various immunological indicators as biomarkers for OIT.

关 键 词：Food allergy Oral immunotherapy BIOMARKER Immune tolerance DESENSITIZATION 

分 类 号：R593.1[医药卫生—内科学]