PTRF/Cavin-1作为外泌体标志物在胶质瘤诊断和治疗中的研究进展  

Research progress of PTRF/Cavin-1 as exosomes marker in diagnosis and treatment of glioma

作　　者：伊凯凯 战琦 王晓光 康春生[2] YI Kai-kai;ZHAN Qi;WANG Xiao-guang(Department of Neurosurgery and Neuro-oncology,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Tianjin 300060,China)

机构地区：[1]天津医科大学肿瘤医院脑系肿瘤科,国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室,天津市恶性肿瘤临床医学研究中心,天津300060 [2]天津市神经病学研究所神经肿瘤研究室,天津医科大学总医院

出　　处：《临床神经外科杂志》2022年第5期511-514,共4页Journal of Clinical Neurosurgery

基　　金：国家自然科学基金(82073322);天津市重点研发计划科技支撑重点项目(20YFZCSY00360);天津市教委自然科学重点项目(2020ZD10)。

摘　　要：脑胶质瘤是中枢神经系统中最常见的原发恶性肿瘤。外泌体在胶质瘤中具有重要的功能及作用,与肿瘤的发生发展密切相关。外泌体不仅可作为肿瘤标志物用于胶质瘤诊断,也可作为药物递送载体用于靶向治疗。本文归纳整理了外泌体在胶质瘤中的作用,并结合近年对聚合酶Ⅰ和转录释放因子(PTRF,又称Cavin-1)作为新型外泌体标志物在胶质瘤诊断及治疗中的研究进行系统梳理,为外泌体在胶质瘤的研究提供参考方向。Glioma is the most common primary malignant tumors of the central nervous system.Acts messengers of intercellular communication,exosomes are closely related to the occurrence and development of glioma.Exosomes can not only be used as tumor markers for glioma diagnosis,but also as drug delivery carriers for targeted therapy.This review aimed to discuss the crucial roles of exosomes in glioma diagnosis and treatment,especially combining the research on a novel marker of glioma-derived exosomes(polymerase-1 and release transcript factor,PTRF,also known as cavin-1).It is highly expected that the better and clearer elucidation of the pivotal roles of exosomes in glioma diagnosis and therapy.

关 键 词：胶质瘤 外泌体 PTRF/Cavin-1 生物标志物 递送载体 

分 类 号：R739.41[医药卫生—肿瘤] R651[医药卫生—临床医学]