Glycogen accumulation drives hepatocarcinogenesis by targeting the Hippo signaling pathway  

作　　者：Weicheng Liang Qi Zhang 

机构地区：[1]Biotherapy Center,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China [2]Cell-gene Therapy Translational Medicine Research Center,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China [3]Vaccine Research Institute,The Third Affiliated Hospital of Sun Yat-sen University,Guangzhou,China

出　　处：《Liver Research》2022年第3期198-200,共3页肝脏研究（英文）

基　　金：This manuscript is supported by grant funded by the National Natural Science Foundation of China(Grant No.81902886).

摘　　要：Recent advances highlight accelerated glucose metabolism as one of the hallmarks of cancer cells.Normal differentiated cells usually utilize the process of mitochondrial oxidative phosphorylation to metabolize glucose into carbon dioxide(CO_(2))and adenosine triphosphate(ATP).However,the cancer cell preferentially takes advantage of aerobic glycolysis to generate lactate and ATP to support the high energy demand for rapid cancer cell proliferation even in the presence of sufficient oxygen.1 This intriguing observation was first reported by the German physiologist Otto Warburg,and thus,this process is termed“the Warburg effect”.

关 键 词：metabolism cancer utilize 

分 类 号：R735.7[医药卫生—肿瘤]