Concurrent severe hepatotoxicity and agranulocytosis induced by Polygonum multiflorum:A case report  

作　　者：You-Lin Shao Chun-Ming Ma Jian-Ming Wu Feng-Cai Guo Suo-Cai Zhang 

机构地区：[1]Department of Hepatology,Changzhou Third People's Hospital,Changzhou 213001,Jiangsu Province,China

出　　处：《World Journal of Clinical Cases》2022年第27期9921-9928,共8页世界临床病例杂志

基　　金：Supported by Applied Basic Research Project of Changzhou,No.CJ20190080。

摘　　要：BACKGROUND Various types of drug-induced liver injury are induced by Polygonum multiflorum(PM);however,it rarely causes neutropenia.Herein,we report the case of a 65-year-old woman with concurrent severe hepatotoxicity and agranulocytosis induced by PM.CASE SUMMARY A 65-year-old woman reported with severe hepatotoxicity and agranulocytosis 17 d after ingestion of PM.The results of the Roussel Uclaf Causality Assessment Method demonstrated a highly probable relationship between hepatotoxicity and PM,with a total score of 10.The Naranjo algorithm results indicated that agranulocytosis had a probable relationship with PM,with an overall score of 6.Granulocyte colony-stimulating factor(for once),a steroid,compound glycyrrhizin,and polyene phosphatidylcholine therapy were initiated.After 15 d of treatment,there was a gradual improvement in liver biochemistry,leukocytes,and neutrophils levels.CONCLUSION Concurrent hepatotoxicity and agranulocytosis are rare and critical adverse drug reactions of PM,which should be highly valued.

关 键 词：Polygonum multiflorum HEPATOTOXICITY AGRANULOCYTOSIS Case report 

分 类 号：R285[医药卫生—中药学]