Drug-induced lung injury caused by acetaminophen in a Japanese woman:A case report  

作　　者：Masayoshi Fujii Tsuneaki Kenzaka 

机构地区：[1]Department of Internal Medicine,Toyooka Public Hospital,Toyooka 668-8501,Japan [2]Department of Internal Medicine,Hyogo Prefectural Tamba Medical Center,Tamba 669-3495,Japan [3]Division of Community Medicine and Career Development,Kobe University Graduate School of Medicine,Kobe 652-0032,Japan

出　　处：《World Journal of Clinical Cases》2022年第27期9936-9944,共9页世界临床病例杂志

摘　　要：BACKGROUND All drugs have the potential to cause drug-induced lung injury both during and after drug administration.Acetaminophen has been reported to cause druginduced lung injury,although this is extremely rare.Herein,we present an extremely rare case of acetaminophen-induced pneumonia.CASE SUMMARY A healthy 35-year-old Japanese woman visited a neighborhood clinic with complaints of fever and malaise following a tick bite.Her treatment included1,500 mg acetaminophen(Caronal^(?)) and subsequently minocycline(200 mg) and acetaminophen(2,000 mg;Caronal^(?)) daily when her condition did not improve;the patient was eventually hospitalized.The patient’s chest computed tomography(CT) revealed consolidation and ground-glass opacities in the right middle and lower lobes.Minocycline was shifted to sulbactam/ampicillin.However,her fever did not improve during follow-up,and her chest CT revealed extensive ground-glass opacities in the right middle and lower lobes and thick infiltrative shadows in the bilateral basal areas.Drug-induced lung injury was suspected;hence,acetaminophen was discontinued.The fever resolved immediately,and inflammatory response and respiratory imaging findings improved.A drug-induced lymphocyte stimulation test was performed against acetaminophen(Caronal^(?)),and significant proliferation of lymphocytes was noted only for acetaminophen(stimulation index,2.1).CONCLUSION Even common drugs such as over-the-counter drugs can cause drug-induced lung damage.

关 键 词：ACETAMINOPHEN Computed tomography Pneumonia Fever Tick bite Case report 

分 类 号：R563[医药卫生—呼吸系统]