Histopathological assessment of the microscopic activity in inflammatory bowel diseases:What are we looking for?  

作　　者：Ondrej Fabian Lukas Bajer 

机构地区：[1]Clinical and Transplant Pathology Centre,Institute for Clinical and Experimental Medicine,Prague 14021,Czech Republic [2]Department of Pathology and Molecular Medicine,3rd Faculty of Medicine,Charles University and Thomayer Hospital,Prague 14059,Czech Republic [3]Hepatogastroenterology Department,Institute for Clinical and Experimental Medicine,Prague 14021,Czech Republic [4]Institute of Microbiology,Czech Academy of Sciences,Prague 14220,Czech Republic

出　　处：《World Journal of Gastroenterology》2022年第36期5300-5312,共13页世界胃肠病学杂志（英文版）

基　　金：Supported by Ministry of Health of the Czech Republic,No. NV18-09-00493 and No. NU21J-06-00027

摘　　要：Advances in diagnostics of inflammatory bowel diseases(IBD)and improved treatment strategies allowed the establishment of new therapeutic endpoints.Currently,it is desirable not only to cease clinical symptoms,but mainly to achieve endoscopic remission,a macroscopic normalization of the bowel mucosa.However,up to one-third of IBD patients in remission exhibit persisting microscopic activity of the disease.The evidence suggests a better predictive value of histology for the development of clinical complications such as clinical relapse,surgical intervention,need for therapy escalation,or development of colorectal cancer.The proper assessment of microscopic inflammatory activity thus became an important part of the overall histopathological evaluation of colonic biopsies and many histopathological scoring indices have been established.Nonetheless,a majority of them have not been validated and no scoring index became a part of the routine bioptic practice.This review summarizes a predictive value of microscopic disease activity assessment for the subsequent clinical course of IBD,describes the most commonly used scoring indices for Crohn's disease and ulcerative colitis,and comments on current limitations and unresolved issues.

关 键 词：Crohn’s disease Microscopy PREDICTOR SCORE Ulcerative colitis 

分 类 号：R574[医药卫生—消化系统]