New insights into the interplay between intestinal flora and bile acids in inflammatory bowel disease  

作　　者：Lie Zheng 

机构地区：[1]Department of Gastroenterology,Shaanxi Hospital of Traditional Chinese Medicine,Xi’an 710003,Shaanxi Province,China

出　　处：《World Journal of Clinical Cases》2022年第30期10823-10839,共17页世界临床病例杂志

基　　金：Supported by General Research of Xi’an Science and Technology Planning Project,No.2022JH-YBYJ-0265;Shaanxi Province Natural Science Basic Research Program-General Project,No.2019JM-580;Project of Shaanxi Administration of Traditional Chinese Medicine,No.2019-ZZ-JC010;Shaanxi Provincial Hospital of Traditional Chinese Medicine,No.2021-07 and No.2018-04。

摘　　要：Intestinal flora plays a key role in nutrient absorption,metabolism and immune defense,and is considered to be the cornerstone of maintaining the health of human hosts.Bile acids synthesized in the liver can not only promote the absorption of fat-soluble substances in the intestine,but also directly or indirectly affect the structure and function of intestinal flora.Under the action of intestinal flora,bile acids can be converted into secondary bile acids,which can be reabsorbed back to the liver through the enterohepatic circulation.The complex dialogue mechanism between intestinal flora and bile acids is involved in the development of intestinal inflammation such as inflammatory bowel disease(IBD).In this review,the effects of intestinal flora,bile acids and their interactions on IBD and the progress of treatment were reviewed.

关 键 词：Intestinal flora Bile acids Inflammatory bowel disease Fecal microbiota transplantation PREBIOTICS 

分 类 号：R574[医药卫生—消化系统]