Role of visfatin in obesity-induced insulin resistance  

作　　者：Mona Mohamed Ibrahim Abdalla 

机构地区：[1]Physiology Department,Human Biology Division,School of Medicine,International Medical University,Kuala Lumpur 57000,Bukit Jalil,Malaysia

出　　处：《World Journal of Clinical Cases》2022年第30期10840-10851,共12页世界临床病例杂志

摘　　要：The growing worldwide burden of insulin resistance(IR) emphasizes the importance of early identification for improved management.Obesity,particularly visceral obesity,has been a key contributing factor in the development of IR.The obesity-associated chronic inflammatory state contributes to the development of obesity-related comorbidities,including IR.Adipocytokines,which are released by adipose tissue,have been investigated as possible indicators of IR.Visfatin was one of the adipocytokines that attracted attention due to its insulinmimetic activity.It is released from a variety of sources,including visceral fat and macrophages,and it influences glucose metabolism and increases inflammation.The relationship between visfatin and IR in obesity is debatable.As a result,the purpose of this review was to better understand the role of visfatin in glucose homeostasis and to review the literature on the association between visfatin levels and IR,cardiovascular diseases,and renal diseases in obesity.

关 键 词：Homeostatic model assessment for insulin resistance Insulin resistance OBESITY VISFATIN pre-B cell colony enhancing factor Nicotinamide phosphoribosyl-transferase enzyme Diabetes ADIPOCYTOKINES 

分 类 号：R589.2[医药卫生—内分泌]