Hyperthermic intraperitoneal chemotherapy and colorectal cancer:From physiology to surgery  

作　　者：Giorgio Ammerata Rosalinda Filippo Carmelo Laface Riccardo Memeo Leonardo Solaini Davide Cavaliere Giuseppe Navarra Girolamo Ranieri Giuseppe Currò Michele Ammendola 

机构地区：[1]Department,Digestive Surgery Unit,University“Magna Graecia”Medical School,Catanzaro 88100,Italy [2]Interventional Oncology Unit with Integrated Section of Translational Medical Oncology,National Cancer Research Centre“Giovanni Paolo Ⅱ”,Bari 70124,Italy [3]Hepato-Biliary and Pancreatic Surgical Unit,“F.Miulli”Hospital,Acquaviva delle Fonti,Bari 70124,Italy [4]Department of Medical and Surgical Sciences,University of Bologna,Forlì40126,Italy [5]Department of General and Oncologic Surgery,Morgagni-Pierantoni Hospital,Forlì47121,Italy [6]Department of Human Pathology of Adult and Evolutive Age,Surgical Oncology Division,“G.Martino”Hospital,University of Messina,Messina 98122,Italy

出　　处：《World Journal of Clinical Cases》2022年第30期10852-10861,共10页世界临床病例杂志

摘　　要：The pursuit of this paper is to collect principal reviews and systematic reviews about hyperthermic intraperitoneal chemotherapy(HIPEC) and cytoreductive surgery(CRS) used in colorectal cancer(CRC).We focus on principal biological aspects of CRC,hyperthermia effects,and surgical procedures.We searched PubMed/MEDLINE for the principal reviews and systematic reviews published from 2010 to 2021 regarding the bimodal treatment(CRS + HIPEC) against local and advanced CRC.In the literature,from several studies,it seems that the efficacy of bimodal treatment with an accurate CRS can extend overall survival.Despite these studies,there are not still any straight guidelines more detailed and scheduled about the use of combined treatment in patients with CRC.Even if the concept is still not very clear and shared,after a careful evaluation of the published data,and after some technical and pathophysiological descriptions,we concluded that it is possible to improve the overall survival and quality of life and to reduce the tumor relapse in patients affected by locally advanced(pT4) CRC with peritoneal metastases.

关 键 词：Hyperthermic intraperitoneal chemotherapy Colorectal cancer PERITONEUM Cytoreductive surgery 

分 类 号：R735.34[医药卫生—肿瘤]