Clinical and epidemiological features of ulcerative colitis patients in Sardinia,Italy:Results from a multicenter study  

作　　者：Salvatore Magrì Mauro Demurtas Maria Francesca Onidi Marcello Picchio Walter Elisei Manuela Marzo Federica Miculan Roberto Manca Maria Pina Dore Bianca Maria Quarta Colosso Antonio Cicu Luigi Cugia Monica Carta Laura Binaghi Paolo Usai Mariantonia Lai Fabio Chicco Massimo Claudio Fantini Alessandro Armuzzi Giammarco Mocci 

机构地区：[1]Department of Medical Sciences and Public Health,University of Cagliari,Monserrato 09042,Italy [2]Endoscopy Unit,Humanitas Istituto Clinico Catanese,Catania 95045,Italy [3]Endoscopy Unit,San Martino Hospital,Oristano 09170,Italy [4]Gastroenterology Unit,Brotzu Hospital,Cagliari 09121,Italy [5]Division of General Surgery,Ospedale Civile P Colombo,Velletri 00049,Italy [6]Gastroenterology Unit,San Camillo Forlanini Hospital,Rome 00152,Italy [7]Internal Medicine and Gastroenterology Department,Cardinale Panico Hospital,Tricase 73039,Italy [8]Department of Surgery,San Martino Hospital,Oristano 09170,Italy [9]Division of Gastroenterology,Santissima TrinitàHospital,Cagliari 09121,Italy [10]Dipartimento di Medicina Clinica e Sperimentale,University of Sassari,Sassari 07100,Italy [11]Department of Medical Science and Public Health,University of Sassari,Sassari 07100,Italy [12]Unit of Gastroenterology,ASL Sassari,Sassari 07100,Italy [13]Gastroenterology Unit,Santissima Annunziata Hospital,Sassari 07100,Italy [14]Medical Science and Public Health,University of Cagliari,Cagliari 09042,Italy [15]Medical Sciences and Public health,Presidio Policlinico of Monserrato,Cagliari,Monserrato 09042,Cagliari,Italy [16]Department of Internal Medicine,University of Rome Tor Vergata,Rome 00133,Italy [17]IBD Unit,Policlinico Universitario Gemelli,Rome 00168,Italy

出　　处：《World Journal of Clinical Cases》2022年第30期10921-10930,共10页世界临床病例杂志

摘　　要：BACKGROUND There are little data on the epidemiological and clinical features of adult patients with ulcerative colitis(UC) in the different Italian regions,mainly derived from the absence of a national registry.This prevents correct interpretation of the disease burden.AIM To assess the main clinical and epidemiological features of adult patients diagnosed with UC in Sardinia,Italy.METHODS We performed a multicenter,observational,cross-sectional study that included adult patients with UC enrolled in seven gastroenterology unit centers in Sardinia.Data were obtained from the patients’ medical records and from a questionnaire administered at the inclusion visit.RESULTS Four hundred and forty-two patients with UC were included.The median age at diagnosis was 39years(interquartile range 28-48).After a median disease duration of 10 years,53 patients experienced proximal extension of proctitis or left-sided colitis.Seventy-five patients developed extraintestinal manifestations.Nineteen patients(4.3%) developed cancer:two with colorectal cancer and seventeen with extracolonic cancers.Mesalazine(5-ASA) remains the mainstay of treatment for UC.Overall,95 patients(21.5%) were treated with one or more biologic agents,whereas 15 patients(3.4%) underwent surgery,mostly colectomy.CONCLUSION Our results provide important insights into the clinical and epidemiological features of patients with UC,and while waiting for a national Italian registry,present eligible data on the UC population in Sardinia.

关 键 词：Inflammatory bowel disease-basic Inflammatory bowel disease-clinical Ulcerative colitis EPIDEMIOLOGY Natural history Treatment 

分 类 号：R574.62[医药卫生—消化系统]