Research progress on the immune microenvironment of the gallbladder in patients with cholesterol gallstones  

作　　者：Jing-Yi Jiao Xiao-Jun Zhu Chun Zhou Peng Wang 

机构地区：[1]Department of Hepatobiliary and Pancreatic Surgery,Affiliated Hospital of Nantong University,Nantong 226001,Jiangsu Province,China [2]Medical School,Nantong University,Nantong 226001,Jiangsu Province,China [3]Department of Hepatobiliary Surgery,Nantong First People's Hospital,Nantong 226001,Jiangsu Province,China [4]Department of General Practitioner,Affiliated Hospital of Nantong University,Nantong 226001,Jiangsu Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2022年第9期887-895,共9页世界胃肠外科杂志（英文版）（电子版）

基　　金：Supported by the Wu Jiping Medical Foundation,No.320.6750.18396;Nantong“14th Five-Year”Science and Education to Strengthen Health Project,General Surgery Medical Key Discipline.

摘　　要：Cholesterol gallstones are very common in hepatobiliary surgery and have been studied to a certain extent by doctors worldwide for decades.However,the mechanism of cholesterol gallstone formation is not fully understood,so there is currently no completely effective drug for the treatment and prevention of cholesterol gallstones.The formation and development of cholesterol gallstones are caused by a variety of genetic and environmental factors,among which genetic susceptibility,intestinal microflora disorders,impaired gallbladder motility,and immune disorders are important in the pathogenesis of cholesterol gallstones.This review focuses on recent advances in these mechanisms.We also discuss some new targets that may be effective in the treatment and prevention of cholesterol gallstones,which may be hot areas in the future.

关 键 词：MICROFLORA Cholesterol gallstones GALLBLADDER PATHOGENESIS Immune disorders 

分 类 号：R657.42[医药卫生—外科学]