Emerging role of psychosis in Parkinson's disease:From clinical relevance to molecular mechanisms  

作　　者：Shuo Zhang Yan Ma 

机构地区：[1]Department of Neurology,Shengjing Hospital of China Medical University,Shenyang 110004,Liaoning Province,China [2]Department of Ultrasound,Shengjing Hospital of China Medical University,Shenyang 110004,Liaoning Province,China

出　　处：《World Journal of Psychiatry》2022年第9期1127-1140,共14页世界精神病学杂志

基　　金：Supported by National Natural Science Foundation of China,No.81801710;Technology Project Funds from Education Department of Liaoning Province of China;345 Talent Project,Shengjing Hospital of China Medical University。

摘　　要：Parkinson's disease(PD)is the second most common neurodegenerative disease.Psychosis is one of the common psychiatric presentations in the natural course of PD.PD psychosis is an important non-motor symptom,which is strongly correlated with a poor prognosis.Increasing attention is being given to PD psychosis.In this opinion review,we summarized and analyzed the identification,screening,epidemiology,mechanisms,risk factors,and therapeutic approaches of PD psychosis based on the current clinical evidence.PD psychosis tends to have a negative effect on patients'quality of life and increases the burden of family caregiving.Screening and identification in the early stage of disease is crucial for establishing tailored therapeutic strategies and predicting the long-term outcome.Development of PD psychosis is believed to involve a combination of exogenous and endogenous mechanisms including imbalance of neurotransmitters,structural and network changes,genetic profiles,cognitive impairment,and antiparkinsonian medications.The therapeutic strategy for PD psychosis includes reducing or ceasing the use of dopaminergic drug,antipsychotics,cholinesterase inhibitors,and non-pharmacological interventions.Ongoing clinical trials are expected to provide new insights for tailoring therapy for PD psychosis.Future research based on novel biomarkers and genetic factors may help inform individualized therapeutic strategies.

关 键 词：PSYCHOSIS Parkinson's disease HALLUCINATIONS DELUSIONS ANTIPSYCHOTICS 

分 类 号：R742.5[医药卫生—神经病学与精神病学]