Delayed improvements in visual memory task performance among chronic schizophrenia patients after high-frequency repetitive transcranial magnetic stimulation  

作　　者：Xiang-Dong Du Zhe Li Nian Yuan Ming Yin Xue-Li Zhao Xiao-Li Lv Si-Yun Zou Jun Zhang Guang-Ya Zhang Chuan-Wei Li Hui Pan Li Yang Si-Qi Wu Yan Yue Yu-Xuan Wu Xiang-Yang Zhang 

机构地区：[1]Suzhou Guangji Hospital,Affiliated Guangji Hospital of Soochow University,Suzhou 215008,Jiangsu Province,China [2]Department of Psychiatry,Third People’s Hospital of Changshu,Changshu 215501,Jiangsu Province,China [3]School of Psychology and Mental Health,North China University of Science and Technology,Langfang 065201,Hebei Province,China [4]Department of Psychiatry,Medical College of Soochow University,Suzhou 215000,Jiangsu Province,China [5]CAS Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China

出　　处：《World Journal of Psychiatry》2022年第9期1169-1182,共14页世界精神病学杂志

基　　金：Supported by Key Diagnosis and Treatment Program of Suzhou,No.LCZX201919 and No.LCZX202016;The Scientific and Technological Program of Suzhou,No.SS201752 and No.SS202069;Introduction Project of Suzhou Clinical Expert Team,No.SZYJTD201715。

摘　　要：BACKGROUND Cognitive impairments are core characteristics of schizophrenia,but are largely resistant to current treatments.Several recent studies have shown that highfrequency repetitive transcranial magnetic stimulation(rTMS)of the left dorsolateral prefrontal cortex(DLPFC)can reduce negative symptoms and improve certain cognitive deficits in schizophrenia patients.However,results are inconsistent across studies.AIM To examine if high-frequency rTMS of the DLPFC can improve visual memory deficits in patients with schizophrenia.METHODS Forty-seven chronic schizophrenia patients with severe negative symptoms on stable treatment regimens were randomly assigned to receive active rTMS to the DLPFC(n=25)or sham stimulation(n=22)on weekdays for four consecutive weeks.Patients performed the pattern recognition memory(PRM)task from the Cambridge Neuropsychological Test Automated Battery at baseline,at the end of rTMS treatment(week 4),and 4 wk after rTMS treatment(week 8).Clinical symptoms were also measured at these same time points using the Scale for the Assessment of Negative Symptoms(SANS)and the Positive and Negative Syndrome Scale(PANSS).RESULTS There were no significant differences in PRM performance metrics,SANS total score,SANS subscores,PANSS total score,and PANSS subscores between active and sham rTMS groups at the end of the 4-wk treatment period,but PRM performance metrics(percent correct and number correct)and changes in these metrics from baseline were significantly greater in the active rTMS group at week 8 compared to the sham group(all P<0.05).Active rTMS treatment also significantly reduced SANS score at week 8 compared to sham treatment.Moreover,the improvement in visual memory was correlated with the reduction in negative symptoms at week 8.In contrast,there were no between-group differences in PANSS total score and subscale scores at either week 4 or week 8(all P>0.05).CONCLUSION High-frequency transcranial magnetic stimulation improves visual memory and reduces negative symptoms in schizophrenia,b

关 键 词：COGNITION High-frequency repetitive transcranial magnetic stimulation Non-invasive brain stimulation Randomized controlled study SCHIZOPHRENIA Visual memory deficits 

分 类 号：R749.3[医药卫生—神经病学与精神病学]