Galectin-3 mediated risk of inflammation in stable schizophrenia,with only possible secondary consequences for cognition  

作　　者：Slavica Minic Janicijevic Ivan P Jovanovic Nevena M Gajovic Milena M Jurisevic Monojit Debnath Nebojsa N Arsenijevic Milica M Borovcanin 

机构地区：[1]University of Kragujevac,Faculty of Medical Sciences,Kragujevac 34000,Serbia [2]Center for Molecular Medicine and Stem Cell Research,Faculty of Medical Sciences,University of Kragujevac,Kragujevac 34000,Serbia [3]Department of Pharmacy,Faculty of Medical Sciences,University of Kragujevac,Kragujevac 34000,Serbia [4]Department of Human Genetics,National Institute of Mental Health and Neurosciences,Bangalore 560029,India [5]Department of Psychiatry,Faculty of Medical Sciences,University of Kragujevac,Kragujevac 34000,Serbia

出　　处：《World Journal of Psychiatry》2022年第9期1183-1193,共11页世界精神病学杂志

基　　金：Supported by Ministry of Science and Technological Development of the Republic of Serbia,No.175069;Faculty of Medical Sciences;University of Kragujevac,No.JP15-05。

摘　　要：BACKGROUND Evidence suggests that cytokines cause immune disturbances,shape immunological sequelae later in life,and modulate the risk of schizophrenia(SC).Galectin-3(Gal-3),a multifaceted molecule of the glycan family,is involved in the formation of the immunological synapse and modulates the signalling pathway and effector functions of T lymphocytes,which are major producers of cytokines.We have previously reported elevated serum Gal-3 levels in stable SC patients.However,Gal-3 as a link between cognitive functioning and inflammation has not yet been investigated in SC.AIM To investigate the relationship between serum Gal-3 levels and cognitive performance,serum cytokines,and white blood cell count in three-month stably treated SC patients.METHODS Twenty-seven patients with SC in remission and 18 healthy volunteers participated in this casecontrol and correlational study.Clinical assessment was performed using the Positive and Negative Syndrome Scale and the Montreal-Cognitive Assessment.The results of previously measured serum levels of Gal-3,interleukin(IL)-33,soluble suppression of tumorigenicity 2(sST2),tumor necrosis factor-alpha(TNF-α),IL-6 and IL-17 were used for further statistical analyses,and IL-4,IL-23,IL-1βand transforming growth factor-beta(TGF-β)were now additionally measured with a sensitive enzyme-linked immunosorbent assay.The number of leukocytes in the blood and the percentage of neutrophils,lymphocytes,and monocytes were determined with a standardized routine measurement procedure(Sysmex Technology).Statistical analyses were performed using SPSS 20.0 software.RESULTS We found no correlation between serum Gal-3 levels and cognitive functioning in SC patients.A positive correlation was found between the levels of Gal-3 and TNF-α(r=0.476;P=0.012),Gal-3and IL-23(r=0.417;P=0.031),and Gal-3 and sST2(r=0.402;P=0.038).The binary logistic model,which included all nine cytokines measured in this patient sample,indicated the particular role of Gal-3 and TGF-βin the duration of SC.In the stabilizat

关 键 词：SCHIZOPHRENIA GALECTIN-3 CYTOKINES Leukocytes ANTIPSYCHOTICS 

分 类 号：R749.3[医药卫生—神经病学与精神病学]