前列地尔、尼麦角林联合治疗VAIV及对血清FGF21、sCD40L、TXB2的影响  

Effects of alprostadil and niergoline combined therapy on SERUM FGF21,sCD40L and TXB2 in patients with VAIV

作　　者：王颖[1] 纪文军[2] 张严 WANG Ying;JI Wen-jun;ZHANG Yan(Department of Neurology,Baoji Central Hospital,Baoji Shaanxi 721000,China;Department of Neurology,Yulin Second Hospital,Yulin Shaanxi 719000,China;Department of Encephalopathy,Baoji Hospital of Traditional Chinese Medicine,Baoji Shaanxi 721000,China)

机构地区：[1]宝鸡市中心医院神经内科,陕西宝鸡721000 [2]榆林市第二医院神经内科,陕西榆林719000 [3]宝鸡市中医医院脑病科,陕西宝鸡721000

出　　处：《临床和实验医学杂志》2022年第17期1809-1813,共5页Journal of Clinical and Experimental Medicine

基　　金：陕西省自然科学基金(编号:2020JM-706)。

摘　　要：目的研究前列地尔、尼麦角林联合治疗后循环缺血性眩晕(VAIV)及对血清成纤维细胞生长因子21(FGF21)、可溶性CD40配体(sCD40L)及血栓素(TXB2)的影响。方法前瞻性选择2019年1月至2021年12月于宝鸡市中心医院治疗的VAIV患者92例,依据随机数字表法分为实验组(n=46)与对照组(n=46)。在常规治疗基础上,对照组给予尼麦角林治疗,实验组给予前列地尔、尼麦角林治疗。观察两组治疗前后基底动脉、两侧椎动脉及颈内动脉等相关动脉血流量,眩晕症状积分,血清FGF21、sCD40L、TXB2水平。并观察临床疗效及不良反应。结果治疗2周后,实验组基底动脉、两侧左椎动脉、右椎动脉及左颈内动脉、右颈内动脉血流量为(35.07±3.78)、(94.05±9.73)、(96.15±9.95)、(390.84±43.18)、(367.75±40.28)mL/min,均大于对照组[(32.12±3.43)、(82.96±8.54)、(85.77±8.93)、(357.07±39.73)、(342.76±38.02)mL/min],差异均有统计学意义(P<0.05)。治疗2周后,实验组眩晕频率、眩晕时间、眩晕程度、伴随症状等眩晕症状各分项积分为(0.49±0.06)、(0.65±0.08)、(0.80±0.09)、(0.79±0.09)分,均小于对照组[(0.68±0.08)、(0.74±0.09)、(1.06±0.13)、(0.96±0.10)分],差异均有统计学意义(P<0.05)。治疗2周后,实验组血清FGF21、sCD40L、TXB2水平为(1.68±0.18)ng/L、(6.58±0.69)ng/mL、(117.84±14.38)μg/L,均低于对照组[(1.97±0.22)ng/L、(9.89±1.01)ng/mL、(126.86±15.75)μg/L],差异均有统计学意义(P<0.05)。实验组总有效率为95.65%,大于对照组(78.26%),差异有统计学意义(P<0.05)。两组均未发生显著不良反应。结论前列地尔、尼麦角林联合治疗VAIV增加后循环血供,改善患者眩晕症状,降低血清FGF21、sCD40L、TXB2水平,疗效好,安全性高。Objective To study the effects of alprostol and niergoline combined therapy on serum fibroblast growth factor 21(FGF21),soluble CD40 ligand(sCD40L)and thromboxane(TXB2)in the treatment of vertebrobasilar arterial insufficiency vertigo(VAIV).Methods A total of 92 patients with VAIV treated in Baoji Central Hospital from January 2019 to December 2021 were prospectively selected and divided into experimental group(n=46)and control group(n=46)according to random number table method.On the basis of conventional treatment,the control group was given niergoline treatment,the experimental group was given alprostadil and niergoline treatment.The blood flow of basilar artery,vertebral artery and internal carotid artery,vertigo symptom score,serum FGF21,sCD40L and TXB2 levels were observed before and after treatment,clinical efficacy and adverse reactions were also observed.Results After 2 weeks of treatment,The blood flow of basilar artery,left vertebral artery,right vertebral artery,left internal carotid artery and right internal carotid artery in the experimental group were(35.07±3.78),(94.05±9.73),(96.15±9.95),(390.84±43.18),(367.75±40.28)mL/min,which were higher than those in the control group[(32.12±3.43),(82.96±8.54),(85.77±8.93),(357.07±39.73),(342.76±38.02)mL/min],the differences were statistically significant(P<0.05).After 2 weeks of treatment,the scores of vertigo symptom in the experimental group were(0.49±0.06),(0.65±0.08),(0.80±0.09),(0.79±0.09)points,which were lower than that in the control group[(0.68±0.08),(0.74±0.09),(1.06±0.13),(0.96±0.10)points],the differences were statistically significant(P<0.05).After 2 weeks of treatment,the levels of FGF21,sCD40L and TXB2 in the experimental group were(1.68±0.18)ng/L,(6.58±0.69)ng/mL,(117.84±14.38)μg/L,which were lower than those in the control group[(1.97±0.22)ng/L,(9.89±1.01)ng/mL,(126.86±15.75)μg/L],the differences were statistically significant(P<0.05).The total effective rate in experimental group was 95.65%,which was higher than tha

关 键 词：后循环缺血性眩晕 前列地尔 尼麦角林 FGF21 sCD40 TXB2 影响 

分 类 号：R743.3[医药卫生—神经病学与精神病学]