胃癌患者经全腹腔镜远端胃癌根治术治疗的前瞻性研究  

Prospective study of totally laparoscopic distal gastrectomy for gastric cancer patients

作　　者：权斌[1] QUAN Bin(Department of General Surgery,Xuzhou Central Hospital,Xuzhou 221000,China)

机构地区：[1]徐州市中心医院普外科,221000

出　　处：《中国现代药物应用》2022年第18期46-49,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨全腹腔镜远端胃癌根治术治疗胃癌的效果。方法124例胃癌患者,采用随机数字表法分为对照组和观察组,每组62例。对照组患者给予腹腔镜辅助远端胃癌根治术治疗,观察组患者给予全腹腔镜远端胃癌根治术治疗。比较两组患者术中指标、术后指标,术后第1、3天的疼痛视觉模拟评分法(VAS)评分,术前、术后1个月的炎性因子[白细胞介素-6(IL-6)、C反应蛋白(CRP)及低氧诱导因子-1α(HIF-1α)]水平,随访1个月并发症发生情况。结果观察组切口长度(2.32±1.03)cm短于对照组的(8.32±2.32)cm,出血量(173.76±33.41)ml少于对照组的(250.53±40.42)ml,差异有统计学意义(P<0.05)。观察组术后首次排气时间(1.86±0.29)d、术后下床活动时间(1.02±0.34)d、术后住院时间(9.34±0.98)d均短于对照组的(4.32±1.18)、(3.87±1.79)、(14.24±2.31)d,差异有统计学意义(P<0.05)。术后第3天,两组VAS评分均低于本组术后第1天,差异具有统计学意义(P<0.05);术后第1、3天,观察组VAS评分分别为(2.56±0.54)、(0.87±0.21)分,均低于对照组的(5.63±1.65)、(4.32±1.45)分,差异有统计学意义(P<0.05)。术后1个月,两组血清IL-6、CRP及HIF-1α水平均低于本组术前,且观察组IL-6(169.65±5.47)pg/ml、HIF-1α(23.43±0.87)pg/ml低于对照组的(190.34±7.34)、(35.76±1.89)pg/ml,差异均具有统计学意义(P<0.05)。随访期间,两组并发症发生率比较差异无统计学意义(P>0.05)。结论采用全腹腔镜远端胃癌根治术治疗胃癌能够减轻患者术中损伤及术后疼痛程度、炎症反应,进一步促进患者术后恢复,安全性良好。Objective To discuss the effect of totally laparoscopic distal gastrectomy in the treatment of gastric cancer.Methods A total of 124 patients with gastric cancer were divided into control group and observation group by random numerical table,with 62 cases in each group.Patients in the control group were treated with laparoscopic-assisted distal gastrectomy for gastric cancer,and patients in the observation group were treated with totally laparoscopic distal gastrectomy for gastric cancer.Both groups were compared in terms of intraoperative and postoperative indicators,visual analogue scale(VAS)score on the 1st and 3rd days after surgery,inflammatory factors[interleukin-6(IL-6),C-reactive protein(CRP),and hypoxia-inducible factor-1α(HIF-1α)]before surgery and 1 month after surgery,and complications at 1-month follow-up.Results The incision length(2.32±1.03)cm in the observation group was shorter than(8.32±2.32)cm in the control group;the blood loss(173.76±33.41)ml in the observation group was less than(250.53±40.42)ml in the control group;the differences were all statistically significant(P<0.05).The postoperative first exhaust time(1.86±0.29)d,postoperative ambulation time(1.02±0.34)d,and postoperative hospital stay(9.34±0.98)d in the observation group were all shorter than(4.32±1.18),(3.87±1.79),and(14.24±2.31)d in the control group,and the differences were statistically significant(P<0.05).On the 3rd day after surgery,the VAS scores of the two groups were lower than those of this group on the 1st day after surgery,and the difference was statistically significant(P<0.05).On the 1st and 3rd day after surgery,the VAS scores of the observation group were(2.56±0.54)and(0.87±0.21)points,which were lower than(5.63±1.65)and(4.32±1.45)points of the control group,and the differences were statistically significant(P<0.05).1 month after surgery,the levels of serum IL-6,CRP and HIF-1αin both groups were lower than those before surgery in this group;the IL-6(169.65±5.47)pg/ml and HIF-1α(23.43±0.87)pg/ml i

关 键 词：胃癌 全腹腔镜远端胃癌根治术 炎性因子 

分 类 号：R735.2[医药卫生—肿瘤]