奥曲肽联合泮托拉唑治疗肝硬化合并上消化道出血的临床效果分析  

Clinical effect analysis of octreotide combined with pantoprazole in the treatment of liver cirrhosis complicated with upper gastrointestinal bleeding

作　　者：赵来峰 ZHAO Lai-feng(Qingyang Traditional Chinese Medicine Hospital,Qingyang 745000,China)

机构地区：[1]甘肃省庆阳市中医医院,745000

出　　处：《中国现代药物应用》2022年第18期130-132,共3页Chinese Journal of Modern Drug Application

摘　　要：目的 分析奥曲肽联合泮托拉唑治疗肝硬化合并上消化道出血的临床效果。方法 86例肝硬化合并上消化道出血患者,采用双盲法分为参照组和治疗组,每组43例。参照组患者采用单一泮托拉唑治疗,治疗组患者采用奥曲肽联合泮托拉唑治疗。对比两组患者治疗后48 h内再出血发生率、治疗效果、症状缓解时间、输血量、止血时间、住院时间。结果 治疗组患者治疗后48 h内再出血发生率6.98%低于参照组的23.26%,治疗优良率95.35%高于参照组的74.42%,差异具有统计学意义(P<0.05)。治疗组患者症状缓解时间(1.01±0.56)d、止血时间(18.11±2.29)h、住院时间(5.56±2.05)d短于参照组的(2.69±1.33)d、(30.52±3.20)h、(8.37±2.26)d,输血量(269.56±45.17)ml少于参照组的(512.01±65.79)ml,差异具有统计学意义(P<0.05)。结论 采用奥曲肽联合泮托拉唑治疗肝硬化合并上消化道出血患者临床疗效显著,能够在短时间内控制出血,改善患者预后,建议在临床治疗中推广使用。Objective To analyze the clinical effect of octreotide combined with pantoprazole in the treatment of liver cirrhosis complicated with upper gastrointestinal bleeding.Methods A total of 86 patients with liver cirrhosis complicated with upper gastrointestinal bleeding were divided into reference group and treatment group by double-blind method,with 43 cases in each group.Patients in the reference group were treated with pantoprazole alone,and patients in the treatment group were treated with octreotide combined with pantoprazole.The incidence of rebleeding within 48 h after treatment,therapeutic effect,symptom remission time,blood transfusion volume,hemostasis time,and hospitalization time were compared between the two groups.Results The incidence of rebleeding 6.98%within 48 h after treatment in the treatment group was lower than 23.26%in the reference group,and the excellent and good rate of treatment 95.35%was higher than 74.42%in the reference group,and the differences were statistically significant(P<0.05).The symptom remission time(1.01±0.56)d,hemostasis time(18.11±2.29)h,and hospitalization time(5.56±2.05)d in the treatment group were shorter than(2.69±1.33)d,(30.52±3.20)h,and(8.37±2.26)d in the reference group,and the blood transfusion volume(269.56±45.17)ml was less than(512.01±65.79)ml in the reference group,and the differences were statistically significant(P<0.05).Conclusion Octreotide combined with pantoprazole has significant clinical efficacy in the treatment of liver cirrhosis complicated with upper gastrointestinal bleeding,and can control the bleeding in a short time,and improve the prognosis of patients.It is recommended to be popularized and used in clinical treatment.

关 键 词：奥曲肽 泮托拉唑 肝硬化合并上消化道出血 治疗有效性 症状缓解时间 

分 类 号：R575.2[医药卫生—消化系统] R573.2[医药卫生—内科学]