20(S)-ginsenoside Rh1 alleviates T2DM induced liver injury via the Akt/FOXO1 pathway  

作　　者：SU Wen-Ya FAN Mei-Ling LI Ying HU Jun-Nan CAI En-Bo ZHU Hong-Yan SONG Ming-Jie LI Wei 

机构地区：[1]College of Chinese Medicinal Materials,Jilin Agricultural University,Changchun 130118,China [2]Maternity Diagnosis&Treatment Center,the Affiliated Hospital of Changchun University of Chinese Medicine,Changchun 130021,China [3]National&Local Joint Engineering Research Center for Ginseng Breeding and Development,Changchun 130118,China

出　　处：《Chinese Journal of Natural Medicines》2022年第9期669-678,共10页中国天然药物（英文版）

基　　金：supported by Jilin Science&Technology Development Plan(No.20200301037RQ).

摘　　要：Diabetes-associated liver injury becomes a dominant hepatopathy,leading to hepatic failure worldwide.The current study was designed to evaluate the ameliorative effects of ginsenoside Rh1(G-Rh1)on liver injury induced by T2DM.A T2DM model was established using C57BL/6 mice through feeding with HFD followed by injection with streptozotocin at 100 mg·kg^(−1).Then the mice were continuously administered with G-Rh1(5 and 10 mg·kg^(−1)),to explore the protective effects of G-Rh1 against liver injury.Results showed that G-Rh1 exerted significant effects on maintaining the levels of FBG and insulin,and ameliorated the increased levels of TG,TC and LDL-C induced by T2DM.Moreover,apoptosis in liver tissue was relieved by G-Rh1,according to histological analysis.Particularly,in diabetic mice,it was observed that not only the increased secretion of G6Pase and PEPCK in the gluconeogenesis pathway,but also inflammatory factors including NF-κB and NLRP3 were suppressed by G-Rh1 treatment.Furthermore,the underlying mechanisms by which G-Rh1 exhibited ameliorative effects was associated with its capacity to inhibit the activation of the Akt/FoxO1 signaling pathway induced by T2DM.Taken together,our preliminary study demonstrated the potential mechnism of G-Rh1 in protecting the liver against T2DM-induced damage.

关 键 词：G-Rh1 Liver injury GLUCONEOGENESIS PEPCK G6Pase Akt/FOXO1 Inflammation 

分 类 号：R965[医药卫生—药理学]