Diverse sesquiterpenoids from Litsea lancilimba Merr.with potential neuroprotective effects against H_(2)O_(2)-induced SH-SY5Y cell injury  

作　　者：ZHANG Yi-Jie BAI Ming LI Jia-Yi QIN Shu-Yan LIU Yu-Yang HUANG Xiao-Xiao ZHENG Jiang SONG Shao-Jiang 

机构地区：[1]Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development,Liaoning Province,Engineering Research Center of Natural Medicine Active Molecule Research&Development,Liaoning Province,Key Laboratory of Natural Bioactive Compounds Discovery&Modification,Shenyang,School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China [2]Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang 110016,China [3]State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Provincial Key Laboratory of Pharmaceutics,Guizhou Medical University,Guiyang 550004,China

出　　处：《Chinese Journal of Natural Medicines》2022年第9期701-711,共11页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.U1812403);the Science and Technology Planning Project of Liaoning Province(No.2021JH1/10400049).

摘　　要：Five undescribed sesquiterpenoids(1–5),and nine known sesquiterpenoids(6–14)were obtained from the fruits of Litsea lancilimba Merr.by LC-MS/MS molecular networking strategies.Litsemene A(1)possessed a unique 8-member ring through unexpected cyclization of the methyl group on C-10 of guaiane.Their structures were elucidated by spectroscopic techniques including IR,UV,NMR,HR-ESI-MS,and their absolute configurations were assigned by ECD calculations.All isolated sesquiterpenoids were analyzed by bioinformatics and evaluated for their neuroprotective effects against H_(2)O_(2)-induced injury in human neuroblastoma SH-SY5Y cells.

关 键 词：Litsea lancilimba LAURACEAE SESQUITERPENOIDS Neuroprotective effect 

分 类 号：R284[医药卫生—中药学] R965[医药卫生—中医学]