细胞焦亡与心血管疾病的关系及中医药干预研究进展  

Relationship and Traditional Chinese Medicine intervention of pyroptosis and cardiovascular diseases

作　　者：尤越 李玲美 李磊[1,2,3] 韩笑 孟红旭[1,2,3] 付建华 刘建勋[1,2,3] YOU Yue;LI Lingmei;LI Lei;HAN Xiao;MENG Hongxu;FU Jianhua;LIU Jianxun(Institute of Basic Medical Sciences of Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;National Clinical Research Center for Chinese Medicine Cardiology,Beijing 100091;Beijing Key Laboratory of Chinese Materia Pharmacology,Beijing 100091)

机构地区：[1]中国中医科学院西苑医院基础医学研究所,北京100091 [2]国家中医心血管病临床医学中心,北京100091 [3]中药药理北京市重点实验室,北京100091

出　　处：《中国比较医学杂志》2022年第9期97-108,共12页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金资助项目(82174219);北京市中医药科技发展基金项目(JJ-2020-78);中国中医科学院科技创新工程项目资助(CI2021A00912);国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-C-202007);北京市中医药科技发展资金青年规划项目(QN-2020-14)。

摘　　要：细胞焦亡(Pyroptosis)是一种促炎的程序性细胞死亡方式,其发生依赖于半胱天冬氨酸蛋白酶(Caspase)的激活,伴随大量促炎症因子释放。细胞焦亡的主要信号通路包括Caspase-1介导的经典通路和Caspase-4、5、11介导的非经典通路。此外,Caspase-3和Caspase-8也可以分别通过裂解Gasdermin E(GSDME)和Gasdermin D(GSDMD)来诱导焦亡。近年来研究表明细胞焦亡在心血管疾病发生发展过程中扮演着重要的角色。本文就细胞焦亡与动脉粥样硬化、心肌缺血/再灌注、心衰、高血压、糖尿病性心肌病这些心血管疾病的关系及近年来中医药调控细胞焦亡干预心血管疾病方面进行综述,以期为发挥中医药优势防治心血管疾病提供新思路。Pyroptosis,a pro-inflammatory programmed mode of cell death that relies on caspases,is accompanied by the massive release of pro-inflammatory factors.There are two main signaling pathways in pyroptosis:the classical pathway mediated by Caspase-1 and non-classical pathway mediated by Caspases-4,5 and 11.In addition,Caspase-3 and Caspase-8 can induce pyroptosis by cleaving Gasdermin E and Gasdermin D,respectively.Recent studies have shown that pyroptosis plays an important role in the occurrence and development of cardiovascular diseases.This article briefly summarizes the relationship between pyroptosis and cardiovascular diseases including atherosclerosis,myocardial ischemia/reperfusion,heart failure,hypertension,and diabetic cardiomyopathy.In addition,we review Traditional Chinese Medicine interventions explored in recent years to provide new ideas for the prevention and treatment of cardiovascular diseases that embrace the advantages of Traditional Chinese Medicine.

关 键 词：中医药 细胞焦亡 心血管疾病 

分 类 号：R-33[医药卫生]