抑郁症动物模型及其在中医药研究运用进展  

Progress on depressive animal models and their application in Traditional Chinese Medicine

作　　者：刘志恒 袁霞红 刘林[1] LIU Zhiheng;YUAN Xiahong;LIU Lin(the First Affiliated Hospital of Hunan Traditional Chinese Medicine University,Changsha 410007,China;Hunan Traditional Chinese Medicine University,Changsha 410208)

机构地区：[1]湖南中医药大学第一附属医院,长沙410007 [2]湖南中医药大学,长沙410208

出　　处：《中国比较医学杂志》2022年第9期109-114,共6页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(82004346,82104793);湖南省自然科学基金(2021JJ30018,2019JJ50461);湖南省科技创新计划资助(2021RC3102);湖南省教育厅项目(20B448,20B433);湖南省中医药管理局重点项目(2021205);湖南中医药大学校级重点项目(2019XJJJ032,2019XJJJ070);湖南中医药大学中医学国内一流建设学科项目(2018-2020);长沙市杰出创新青年培养计划项目(kq1802008)。

摘　　要：目前抑郁症临床西药治疗上存在着毒副作用大、停药后容易反复等问题,急切需要中医药治疗手段的参与,同时也需要中医药相关方面的基础研究。但在其基础研究中,动物实验面临着相关的问题,即基于现代医学病因病理理论的抑郁症动物模型不能很好地适用于中医药研究。所以把疾病模型和证候模型相结合以构建适用于中医药动物实验的病证结合动物模型。本文以目前运用于抑郁症的病证结合动物模型的制备以及相关研究为切入点,以求使其更科学合理应用到中医药创新研究。There are many problems in the clinical treatment of depression,such as the high toxicity and side effects of drugs,and high relapse rate after medication withdrawal.Accordingly,there is an urgent need for the application of Traditional Chinese Medicine approaches.Likewise,increased basic research of Traditional Chinese Medicine is also needed.However,use of animal experiments for basic research creates some problems.In particular,animal models of depression based on modern medical etiology and pathology theory cannot be well applied to research of Traditional Chinese Medicines.Therefore,disease and syndrome models are often combined to construct a combination model of disease and syndrome suitable for animal experiments of Traditional Chinese Medicines.This article describes the preparation of a combination disease and syndrome model that uses correlative research as the starting point to make it more scientifically and reasonably applied to innovative research of Traditional Chinese Medicines.

关 键 词：抑郁症 郁证 中医药 动物模型 病证结合模型 

分 类 号：R-33[医药卫生]