NLRP1在头颈部鳞癌中的表达及预后意义  

Comprehensive co-expression analysis revealed NLRP1 as a prognostic immune-associated gene in head and neck squamous cell carcinoma

作　　者：杨慧丽 王宇帆[2] 王锋[2] 沈月洪 杨宏宇 YANG Hui-li;WANG Yu-fan;WANG Feng;SHEN Yue-hong;YANG Hong-yu(Department of General Dentistry Il,Peking University School and Hospital of Stomatology,National Center of Stomatology,National Clinical Research Center for Oral Diseases,National Engineering Research Center of Oral Biomaterials and Digital Medical Devices,Beijing 100081;Department of Oral and Maxillofacial Surgery,Stomatological Center,Peking University Shenzhen Hospital,Guangdong Provincial High-Level Clinical Key Specialty,Guangdong Province Engineering Research Center of Oral Disease Diagnosis and Treatment,Shenzhen 518036,Guangdong Province,China)

机构地区：[1]北京大学口腔医学院·口腔医院综合二科,国家口腔医学中心,国家口腔疾病临床医学研究中心,口腔生物材料和数字诊疗装备国家工程研究中心,北京100081 [2]北京大学深圳医院口腔医学中心口腔颌面外科,广东省高水平临床重点专科,广东省口腔疾病诊疗技术工程技术研究中心,广东深圳518036

出　　处：《中国口腔颌面外科杂志》2022年第5期429-436,共8页China Journal of Oral and Maxillofacial Surgery

基　　金：广东省基础与应用基础研究基金(2019A1515011911);深圳市科技创新委员会基础研究重点项目基金(JCYJ20200109140208058)。

摘　　要：目的:研究含热蛋白结构域的NOD样受体蛋白1(NLRP1)在头颈部鳞癌(HNSCC)中的表达、预后价值及免疫相关性。方法:通过基于癌症基因组图谱(TCGA)数据库的多个在线网站,分析NLRP1表达及在HNSCC中的预后价值,并通过GO、KEGG分析,明确其参与的生物过程及信号通路。结果:NLRP1在HNSCC中上调,NLRP1的高表达与较长的总生存期呈正相关。功能网络分析及共表达分析表明,NLRP1与先天免疫及炎症等相关,在多个免疫相关的信号通路中发挥作用。此外,在HNSCC中,NLRP1的表达与中性粒细胞、CD4^(+)T细胞、树突状细胞的浸润呈正相关,NLRP1与HNSCC中的多种免疫标志物相关。结论:NLRP1在HNSCC中高表达,NLRP1的高表达可改善预后,可作为HNSCC的潜在预后标志物。NLRP1在先天免疫反应和炎症反应中发挥作用,NLRP1高表达与HNSCC中CD4+T细胞、中粒细胞、树突状细胞的浸润程度呈正相关。PURPOSE:To explore the prognostic value and mechanism of NLR family, pyrin domain containing 1(NLRP1) in head and neck squamous cell carcinoma(HNSCC). METHODS:This study performed bioinformatics analysis on HNSCC data from The Cancer Genome Atlas(TCGA), and jointly analyzed with online databases such as TIMER, TCGA-portal, Kaplan-Meier Plotter, LinkedOmics, GeneMANIA, Metascape, TISIDB and miRDB. RESULTS:NLRP1 was upregulated in HNSCC. Kaplan-Meier survival analysis indicated that patients with high NLRP1 expression had a better prognosis than those with low expression. Furthermore, NLRP1 was concentrated in multiple immune-associated signaling pathways and the expression of NLRP1 was associated with the infiltration of CD4^(+)T cells, neutrophils and dendritic cells.CONCLUSIONS:Our findings confirmed that NLRP1 is highly expressed in HNSCC. The high expression of NLRP1 was significantly related to prognosis and the infiltration degree of CD4+T cells, neutrophils and dendritic cells in HNSCC.

关 键 词：NLRP1 头颈部鳞癌 生物标志物 预后 免疫浸润 

分 类 号：R739.8[医药卫生—肿瘤]