多模态影像学研究帕金森病伴左旋多巴诱导异动症进展  

Research progresses of multimodal imaging for Parkinson disease complicated with levodopa-induced dyskinesia

作　　者：宋天彬[1,2] 卢洁 SONG Tianbin;LU Jie(Department of Radiology and Nuclear Medicine,Xuanwu Hospital Capital Medical University,Beijing 100053,China;Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院放射与核医学科,北京100053 [2]磁共振成像脑信息学北京市重点实验室,北京100053

出　　处：《中国医学影像技术》2022年第10期1567-1570,共4页Chinese Journal of Medical Imaging Technology

基　　金：首都医科大学宣武医院“汇智”人才工程学者计划(HZ2021ZCLJ005)。

摘　　要：帕金森病(PD)是常见神经退行性疾病;左旋多巴诱导异动症(LID)是PD患者长期服用左旋多巴药物所致常见致残性运动并发症。MR结构成像、功能MRI及PET显像可观察LID患者脑结构、功能及代谢改变,为阐述脑相关发病机制提供多模态影像学依据,有助于临床早期诊断。本文就多模态影像学研究PD伴LID进展进行综述。Parkinson disease(PD)is a common neurodegenerative disease,and levodopa-induced dyskinesia(LID)is the common disabling motor complication caused by PD patients taken levodopa drugs for a long time.MR structural imaging,functional MRI and PET imaging can be used to observe the changes of brain structures,functions and metabolisms of LID patients,providing multimodal imaging basis for explaining the brain related pathogenesis,hence being helpful for early clinical diagnosis.The research progresses of multimodal imaging for PD complicated with LID were reviewed in this article.

关 键 词：帕金森病 左旋多巴 舞蹈症 磁共振成像 正电子发射断层显像 

分 类 号：R742[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学] R817.4