胞二磷胆碱注射液联合替格瑞洛片治疗脑梗死患者的效果  

Effects of Citicoline injection combined with Ticagrelor tablets in treatment of cerebral infarction

作　　者：赵少华 ZHAO Shaohua(Department of Neurology of Dengfeng People’s Hospital,Dengfeng 452470 Henan,China)

机构地区：[1]登封市人民医院神经内科,河南登封452470

出　　处：《中国民康医学》2022年第18期61-63,67,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察胞二磷胆碱注射液联合替格瑞洛片治疗脑梗死患者的效果。方法:回顾性分析2019年1月至2020年12月该院收治的96例脑梗死患者的临床资料,按照治疗方法不同分为对照组和观察组各48例。对照组采用替格瑞洛片治疗,观察组在对照组基础上联合胞二磷胆碱注射液治疗。治疗14 d,比较两组治疗效果,治疗前后血液流变学指标(全血低切黏度、全血高切黏度、血浆黏度)水平和神经元特异性烯醇化酶(NSE)、同型半胱氨酸(Hcy)、胱抑素C(CysC)水平,以及不良反应发生率。结果:观察组治疗总有效率为95.83%,高于对照组的83.33%,差异有统计学意义(P<0.05);治疗后,两组全血高切黏度、全血低切黏度和血浆黏度均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组NSE、Hcy和CysC水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:胞二磷胆碱联合替格瑞洛治疗脑梗死患者可提高治疗总有效率,降低血液流变学指标水平和NSE、Hcy、CysC水平,效果优于单纯替格瑞洛治疗。Objective:To observe effects of Citicoline injection combined with Ticagrelor tablets in treatment of cerebral infarction.Methods:The clinical data of 96 patients with cerebral infarction admitted to this hospital from January 2019 to December 2020 were retrospectively analyzed,and they were divided into control group and observation group according to different treatment methods,48 cases in each group.The control group was treated with Ticagrelor tablets,while the observation group was treated with Citicoline injection on the basis of that of the control group.The treatment lasted for 14 days.The therapeutic effects,the levels of hemorheology indexes(whole blood low-shear viscosity,whole blood high-shear viscosity,plasma viscosity),the levels of neuron-specific enolase(NSE),homocysteine(Hcy),Cystatin C(CysC),and incidence of adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate of treatment in the observation group was 95.83%,which was higher than 83.33%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of whole blood high shear viscosity,whole blood low shear viscosity and plasma viscosity in the two groups were significantly lower than those before the treatment,those of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).The levels of NSE,Hcy and CysC in the two groups were significantly lower than those before the treatment,those of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Citicoline combined with Ticagrelor in the treatment of the patients with cerebral infarction can improve the total effective rate of treatment and reduce the levels of hemorheology indexes and the levels of NSE,Hcy and CysC.Moreover,it is supe

关 键 词：脑梗死 替格瑞洛 胞二磷胆碱注射液 血液流变学 不良反应 

分 类 号：R743.3[医药卫生—神经病学与精神病学]