抗Ri抗体阳性的神经系统副肿瘤综合征研究进展  

Advances in the study of nervous system paraneoplastic syndrome with positive anti Ri antibody

作　　者：李自超[1] 葛朝明[1,2] Li Zichao;Ge Zhaoming(Department of Neurology,Second Hospital of Lanzhou University,Gansu Province,Lanzhou 730000,China;不详)

机构地区：[1]兰州大学第二医院神经内科,730000 [2]甘肃省神经内科临床医学研究中心,兰州730000

出　　处：《疑难病杂志》2022年第10期1113-1116,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：甘肃省科技计划项目(20JR10FA663)。

摘　　要：近年来,随着对副肿瘤综合征机制研究的兴起,神经系统副肿瘤综合征(PNS)的表现与发病机制也成为临床研究的重点。神经系统副肿瘤综合征是指肿瘤的产物作用于体内神经系统的共同抗原,发生交叉免疫反应累及神经系统,如大脑皮质、小脑、脑干、周围神经引起相应神经功能缺损的一组临床综合征。此类患者常为急性或亚急性起病,预后不佳。现对神经系统副肿瘤抗体的系统研究仍不足,而了解神经副肿瘤抗体对机体的免疫反应是制定相应治疗策略的关键。文章对抗Ri抗体阳性PNS患者的发现起源、发病机制、临床表现、诊断、治疗及预后进行综述。In recent years,with the rise of research on the mechanism of paraneoplastic syndrome,the manifestations and pathogenesis of nervous system paraneoplastic syndrome(PNS) have become the focus of clinical research.Paraneoplastic syndrome of the nervous system refers to a group of clinical syndromes in which the products of tumors act on the common antigens of the nervous system in the body and cross immune reactions affect the nervous system,such as cerebral cortex,cerebellum,brain stem,and peripheral nerves,causing corresponding neurological deficits.Such patients often have acute or subacute onset and poor prognosis.At present,the systematic research on the antineoplastic antibodies of the nervous system is still insufficient,and understanding the immune response of the antineoplastic antibodies of the nervous system to the body is the key to formulate corresponding treatment strategies.This article reviews the origin,pathogenesis,clinical manifestations,diagnosis,treatment and prognosis of anti Ri antibody positive PNS patients.

关 键 词：神经系统副肿瘤综合征 肿瘤 抗Ri抗体 

分 类 号：R73[医药卫生—肿瘤] R747.9[医药卫生—临床医学]