电抽搐治疗对精神分裂症海马影响的磁共振成像研究进展  

Progress of magnetic resonance imaging studies on the antipsychotic effect of electroconvulsive therapy on the hippocampus

作　　者：夏梦青 王继军[1] 李春波[1,2] XIA Mengqing;WANG Jijun;LI Chunbo(Shanghai Jiao Tong University School of Medicine,Shanghai Mental Health Center,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心,上海200030 [2]上海市重性精神病重点实验室

出　　处：《中国神经精神疾病杂志》2022年第7期444-448,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：国家自然科学基金(编号:81971251);上海市精神心理临床医学研究中心项目(编号:19MC1911100)。

摘　　要：电抽搐治疗精神疾病的作用机制尚不明确,其他精神疾病研究表明电抽搐治疗对大脑海马部位神经可塑性具有影响。海马损伤存在于精神分裂症的各个阶段,电抽搐治疗精神分裂症的机制也可能与海马有关。本文从结构磁共振、功能磁共振、磁共振波谱方面综述电抽搐治疗前后精神分裂症患者海马的磁共振影像学变化,发现电抽搐治疗可以致精神分裂症患者海马及临近部位的体积增加,改变海马与其他脑区功能连接的强度,这些变化可能与精神症状改善有关,而基线的一些影像学特征可能对电抽搐治疗的效果有潜在预测价值。The antipsychotic mechanism of electroconvulsive therapy(ECT)is still unclear,while the neurotrophic effect in hippocampus was found to be the most consistent finding in the antidepressant research.Hippocampal abnormalities existed in all stages of schizophrenia,reminding that the antipsychotic effect of ECT may also be related to the hippocampus.We reviewed the magnetic resonance imaging research of schizophrenia focusing on the longitudinal changes of hippocampus during ECT,and found that ECT can also induce volume increase of the hippocampus and adjacent parts,as well as functional connection alteration between the hippocampus and other brain regions in schizophrenia.These changes seemed to be related to the relief of symptoms,and some imaging features at baseline may have potential predictive value for the antipsychotic effect of ECT.

关 键 词：电抽搐治疗 海马 精神分裂症 结构磁共振 功能磁共振 磁共振波谱 作用机制 

分 类 号：R749.3[医药卫生—神经病学与精神病学]