胰腺星状细胞在胰腺癌治疗中的应用价值研究进展  

Research progress on the application value of pancreatic stellate cells in the treatment of pancreatic cancer

作　　者：李微波 常剑 熊星铖[1] 汤志刚[1] LI Weibo;CHANG Jian;XIONG Xingcheng;TANG Zhigang(Department of General Surgery,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院普通外科,湖北武汉430060

出　　处：《中国普通外科杂志》2022年第9期1243-1248,共6页China Journal of General Surgery

基　　金：国家自然科学基金资助项目(81272740)。

摘　　要：胰腺癌因其复杂的肿瘤微环境(TME),具有恶性程度高、进展快、转移早、化疗耐药及无特殊靶向药物等特点。胰腺星状细胞(PSCs)是胰腺的常驻脂质储存细胞,是TME的重要组成部分,靶向TME中的肿瘤-基质串扰已成为一种有前途的抗胰腺癌进展和转移的治疗策略。因此,笔者就PSCs在胰腺癌TME中的相互作用及靶向活化PSCs的潜在治疗应用进行综述,以期为胰腺癌的治疗提供新靶点和新思路。Pancreatic cancer is characterized by high malignancy,rapid progression,early metastasis,chemotherapy resistance,and no specific targeted drugs due to its complex tumor microenvironment(TME).Pancreatic stellate cells(PSCs) are inert lipid storage cells of the pancreas and an important part of the TME.Targeting tumor-stromal crosstalk in the TME has become a promising therapeutic strategy against pancreatic cancer progression and metastasis.Therefore,the authors address the interaction of PSCs in the pancreatic cancer TME and the potential treatment application of targeted activation of PSCs,to provide new targets and new ideas for the treatment of pancreatic cancer.

关 键 词：胰腺肿瘤/治疗 肿瘤微环境 胰腺星形细胞 综述 

分 类 号：R736.7[医药卫生—肿瘤]