胰腺导管腺癌微环境中星状细胞对肿瘤新生血管影响的研究进展  

Research progress on the effect of stellate cells in pancreatic ductal adenocarcinoma microenvironment on tumor angiogenesis

作　　者：刘娇 赵建国[2] LIU Jiao;ZHAO Jianguo(Graduate School,Inner Mongolia Medical University,Hohhot 010050,China;Department of Hepatobiliary Surgery,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学研究生院,内蒙古呼和浩特010050 [2]内蒙古医科大学附属医院肝胆外科,内蒙古呼和浩特010050

出　　处：《中国普通外科杂志》2022年第9期1249-1254,共6页China Journal of General Surgery

基　　金：国家自然科学基金资助项目(82060432);内蒙古自治区自然科学基金资助项目(2019MS08025);内蒙古自治区科技攻关计划基金资助项目(2019GG085)

摘　　要：胰腺导管腺癌(PDAC)是恶性程度最高的消化系统肿瘤,其诊断晚、转移早、预后差,5年生存率不足7%。虽然严重的间质纤维化以及乏血供为PDAC组织的重要特点,但肿瘤细胞周围常伴有大量的新生血管。许多细胞因子通过胰腺星状细胞(PSCs)这个“桥梁”直接或间接对肿瘤血管生成起着重要的促进作用,但其具体作用机制不是很明确。同时也有实验结果显示,活化的PSCs分泌的半乳糖凝集素1(galectin-1)和肝细胞生长因子(HGF)与血管内皮生长因子(VEGF)表达成正相关。肿瘤血管生成是肿瘤的特征之一,血管生成对于PDAC的持续生长、侵袭和转移至关重要。但目前对于PDAC肿瘤血管生成的研究相对较少,笔者就PDAC微环境中PSCs对PDAC的血管生成影响展开相关论述,并探讨了靶向PSCs阻断其功能的潜在癌症治疗策略。Pancreatic ductal adenocarcinoma(PDAC)is the most malignant digestive tumor and is characterized by late detection,early metastasis,and poor prognosis,with a 5-year survival rate of less than 7%.Although severe interstitial fibrosis and lack of blood supply are important features of PDAC tissue,the tumor cells are often accompanied by intense neovascularization.Many cytokines play important roles in promoting tumor angiogenesis directly or indirectly through the bridge of the pancreatic stellate cells(PSCs),but thein specific action mechanism is not entirely clear.Meanwhile,experimental results also showed that the expression of vascular endothelial growth factor(VEGF)was positively correlated with the secretion of galectin-1 and hepatocyte growth factor(HGF)from activated PSCs.Tumor angiogenesis is one of the characteristics of tumors,and angiogenesis is essential for the continuous growth,invasion,and metastasis of PDAC.However,there are relatively few studies on PDAC angiogenesis.Here,the authors address the effects of PSCs in the PDAC microenvironment on tumor angiogenesis,and the potential cancer treatment strategies targeting PSCs to block their function are also discussed.

关 键 词：胰腺肿瘤 胰腺星形细胞 新生血管化 病理性 肿瘤微环境 综述 

分 类 号：R736.7[医药卫生—肿瘤]