急性缺血性脑卒中与血浆细胞因子相关性分析研究  

Correlation between acute ischemic stroke and plasma cytokines

作　　者：邢媛 张楠 申致远 王晓[1,2] 张雨晴 唐鲜 闻振业 田书娟 XING Yuan;ZHANG Nan;SHEN Zhiyuan;WANG Xiao;ZHANG Yuqing;TANG Xian;WEN Zhenye;TIAN Shujuan(Department of Neurology,The First Hospital of Hebei Medical University,Shijiazhuang 050031,China;Brain Aging and Cognitive Neuroscience Key Laboratory of Hebei province,Shijiazhuang 050031,China;Central Laboratory,The First Hospital of Hebei Medical University,Shijiazhuang 050031,China;Rehabilitation Department,The First Hospital of Hebei Medical University,Shijiazhuang 050031,China)

机构地区：[1]河北医科大学第一医院神经内科,石家庄050031 [2]河北省脑老化与认知神经科学重点实验室,石家庄050031 [3]河北医科大学第一医院中心实验室,石家庄050031 [4]河北医科大学第一医院康复科,石家庄050031

出　　处：《重庆理工大学学报（自然科学）》2022年第9期305-311,共7页Journal of Chongqing University of Technology：Natural Science

基　　金：河北省医学科学研究课题计划(20210916,20211628)。

摘　　要：目的分析急性缺血性脑卒中的病情与炎性细胞因子之间的相关性。方法选择2020年3月至2021年12月河北医科大学第一医院神经内科收治的急性缺血性脑卒中(AIS)患者71例,另选同期与AIS组年龄和性别匹配的健康对照者76例。使用Navios流式细胞仪分析血浆中11种细胞因子水平变化,包括IL-2、IL-4、IL-5、IL-6、IL-8、IL-10、IL-12P70、IL-17A、干扰素-α(IFN-α)、干扰素-γ(IFN-γ)及IL-1β。分析比较两组受试者的一般资料及细胞因子水平的变化。结果AIS组与对照组相比,白细胞水平及血红蛋白水平明显升高(P<0.05),但11项细胞因子水平未见明显差异(P>0.05)。在AIS组中,IL-2及IL-10均与AIS入院时NIHSS评分严重程度成正相关(IL-2:r=0.254,P=0.033;IL-10:r=0.319,P=0.007);并且IFN-α与住院天数呈正相关(r=0.251,P=0.034)。结论急性缺血性脑卒中患者的IL-2和IL-10水平与发病时NIHSS评分严重程度呈正相关,IFN-α与住院天数呈正相关,细胞因子水平在急性缺血性脑卒中的疾病程度判断方面具有临床应用价值。Objective:This study retrospectively analyzes the correlation between acute ischemic stroke(AIS)and inflammatory cytokines.Methods:71 patients diagnosed with AIS in the Department of Neurology of the First Hospital of Hebei Medical University from March 2020 to December 2021 are served as AIS group.And 76 age-and sex-mathced persons during the same period serve as control group.The levels of IL-2,IL-4,IL-5,IL-6,IL-8,IL-10,IL-12 p70,IL-17 A,interferon-α(IFN-α),IFN-γand IL-1βin plasma are analyzed by Navios flow cytometry.The general data and cytokine levels of the two groups are analyzed and compared.Results:Compared with the control group,the levels of leukocytes and hemoglobin in AIS group are significantly higher(P<0.05),but there is no significant difference in the levels of 11 cytokines(P>0.05).In the AIS group,IL-2 and IL-10 are positively correlated with the severity of NIHSS score at admission(IL-2:r=0.254,P=0.033;IL-10:r=0.319,P=0.007).And IFN-αis positively correlated with the length of hospital stay(r=0.251,P=0.034).Conclusion:The levels of IL-2 and IL-10 in patients with AIS are positively correlated with the severity of NIHSS and the level of IFN-αis positively correlated with the length of hospital stay.The level of cytokines has potential clinical value in judging the estimating the state of acute ischemic stroke.

关 键 词：急性缺血性脑卒中 细胞因子 白介素-2 白介素-10 干扰素-Α 

分 类 号：R743.3[医药卫生—神经病学与精神病学]