反射式共聚焦激光扫描显微镜在光动力治疗日光性角化后随访中的应用  

Applications of reflectance confocal microscopy in follow-up of actinic keratosis after 5-aminolevulinic acid photodynamic therapy

作　　者：顾静 邹云敏 冯广东 GU Jing;ZOU Yunmin;FENG Guangdong(The Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University,Wuxi 214000,China)

机构地区：[1]南京医科大学附属无锡第二医院皮肤科,无锡214000

出　　处：《中国麻风皮肤病杂志》2022年第11期794-796,共3页China Journal of Leprosy and Skin Diseases

基　　金：无锡市卫生健康委科研项目(编号:Q202141)。

摘　　要：目的:明确反射式共聚焦激光扫描显微镜检查在光动力治疗日光性角化后随访中的应用价值。方法:对16例日光性角化患者光动力治疗后1个月、3个月、6个月分别于治疗部位行RCM扫描,如RCM扫描发现肿瘤细胞,则进一步行组织病理学检查明确诊断。结果:16例患者完成治疗后均规律复诊,并行RCM检查。其中1例光动力治疗后1个月复查,RCM下发现肿瘤细胞。2例光动力治疗后3个月复查,RCM下发现肿瘤细胞。3例均再进一步行组织病理学检查诊断明确日光性角化,其余13例患者随访6个月未发现复发。结论:RCM在光动力治疗日光性角化后随访中具有重要的应用价值。Objective:To determine the application value of reflectance confocal microscopy in follow-up of actinic keratosis after 5-aminolevulinic acid photodynamic therapy.Methods:RCM scanning was performed in 16 patients with actinic keratosis at 1 month,3 months and 6 months after 5-aminolevulinic acid photodynamic therapy.Histological examination was performed in patients with tumor tissue found by RCM.Results:RCM regular reexamination was performed in 16 patients,tumor cells were found in 1 case at 1 month after therapy,and tumor cells were found in 2 cases at 3 months after therapy.All 3 patients were diagnosed with actinic keratosis by histological examination again.No tumor cells were found in the other 13 patients after follow-up for 6 months.Conclusions:RCM has important application value in follow-up of actinic keratosis after photodynamic therapy.

关 键 词：反射式共聚焦激光扫描显微镜 日光性角化 光动力 

分 类 号：R739.5[医药卫生—肿瘤]